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miR-592 的异常表达与肾细胞癌的预后和进展相关。

Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma.

作者信息

Lv Xianbao, Shen Jingang, Guo Zhen, Kong Lingwei, Zhou Guangchun, Ning Hao

机构信息

Department of Urology, Chengwu People's Hospital, Heze, Shandong, 274200, People's Republic of China.

Department of Urology, Central Hospital Affiliated Shandong First Medical University, Jinan, Shandong, 250033, People's Republic of China.

出版信息

Onco Targets Ther. 2019 Dec 18;12:11231-11239. doi: 10.2147/OTT.S227834. eCollection 2019.

DOI:10.2147/OTT.S227834
PMID:31908489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6927226/
Abstract

PURPOSE

MicroRNAs have recently reported playing a vital role in the development of cancers. However, the role of miR-592 in renal cell carcinoma (RCC) has not been explored. In this study, the potential role of miR-592 was investigated in RCC.

PATIENTS AND METHODS

The expression of miR-592 was evaluated in RCC tissues and cell lines using qRT-PCR assays. The Kaplan-Meier analysis and Cox proportional hazards model analysis was used to analyze the prognostic value of miR-592 in RCC. The effects of miR-592 on cell proliferation, migration, and invasion were determined by cell counting kit-8 (CCK-8) and Transwell assays in vitro.

RESULTS

The results showed that miR-592 was significantly increased both in RCC tissues and cell lines. Overexpression of miR-592 was significantly associated with lymph node metastasis, TNM stage, and poor overall survival. And functional studies in two RCC cell lines (786-O and Caki-1) have shown that overexpression of miR-592 promoted cell proliferation, migration, and invasion, while silence of miR-592 inhibited cell proliferation, migration, and invasion. SPRY2 was a direct target of miR-592.

CONCLUSION

Overall, overexpression of miR-592 may be a prognostic biomarker and therapeutic strategy for patients with RCC, which is correlated with the progression of RCC.

摘要

目的

最近有报道称微小RNA在癌症发展中起着至关重要的作用。然而，miR - 592在肾细胞癌（RCC）中的作用尚未得到探索。在本研究中，我们调查了miR - 592在RCC中的潜在作用。

患者与方法

使用qRT - PCR检测法评估RCC组织和细胞系中miR - 592的表达。采用Kaplan - Meier分析和Cox比例风险模型分析来分析miR - 592在RCC中的预后价值。通过体外细胞计数试剂盒 - 8（CCK - 8）和Transwell检测法确定miR - 592对细胞增殖、迁移和侵袭的影响。

结果

结果显示，miR - 592在RCC组织和细胞系中均显著升高。miR - 592的过表达与淋巴结转移、TNM分期及总体生存率差显著相关。在两种RCC细胞系（786 - O和Caki - 1）中的功能研究表明，miR - 592的过表达促进细胞增殖、迁移和侵袭，而miR - 592的沉默则抑制细胞增殖、迁移和侵袭。SPRY2是miR - 592的直接靶点。

结论

总体而言，miR - 592的过表达可能是RCC患者的一种预后生物标志物和治疗策略，它与RCC的进展相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/737c8d307975/OTT-12-11231-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/da196d922e2b/OTT-12-11231-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/11ec4ea604a0/OTT-12-11231-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/65bd62cc6c09/OTT-12-11231-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/9576a74f2735/OTT-12-11231-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/737c8d307975/OTT-12-11231-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/da196d922e2b/OTT-12-11231-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/11ec4ea604a0/OTT-12-11231-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/65bd62cc6c09/OTT-12-11231-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/9576a74f2735/OTT-12-11231-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57a5/6927226/737c8d307975/OTT-12-11231-g0005.jpg

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2
Causes of Death and Conditional Survival of Renal Cell Carcinoma.肾细胞癌的死亡原因及条件生存情况
Front Oncol. 2019 Jul 15;9:591. doi: 10.3389/fonc.2019.00591. eCollection 2019.
3
Circulating MicroRNAs in Cancer: Potential and Challenge.
肾细胞癌中的微小RNA特征
Front Oncol. 2020 Nov 30;10:596359. doi: 10.3389/fonc.2020.596359. eCollection 2020.
4
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Genes (Basel). 2020 Mar 2;11(3):271. doi: 10.3390/genes11030271.
癌症中的循环微小RNA：潜力与挑战
Front Genet. 2019 Jul 18;10:626. doi: 10.3389/fgene.2019.00626. eCollection 2019.
4
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6
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