Insani Dina A, Subagio Hertanto W, Hendrianingtyas Meita
Clinical Nutrition Department, Diponegoro University, Semarang, Central Java, Indonesia.
Clinical Pathology Department, Diponegoro University, Semarang, Central Java, Indonesia.
J Taibah Univ Med Sci. 2019 Nov 7;14(6):531-537. doi: 10.1016/j.jtumed.2019.08.007. eCollection 2019 Dec.
Overweight is considered a risk factor for anaemia. However, the mechanisms underlying anaemia development in overweight and obese people remain unclear. This study analysed the correlation of iron status (soluble transferrin receptor [sTfR]/log ferritin ratio) and hepcidin levels with haemoglobin (Hb) levels in overweight and obese women of childbearing age.
In this cross-sectional study, we recruited 66 women aged 20-29 years with a body mass index ≥23 kg/m. We gathered data on informed consent, demographic characteristics, questionnaire responses, anthropometric and laboratory values. A Spearman correlation test was performed to determine the correlation.
The mean levels of ferritin and sTfR were 10.2 ± 8.12 and 22.2 ± 7.96 ng/ml, respectively, and the mean sTfR/log ferritin ratio was 29.3 ± 17.65 nmol/L. The mean hepcidin levels were 9.0 ± 3.05 ng/ml. In total, 75.8% of subjects had low ferritin levels, high sTfR (51.5%) levels, and a high sTfR/log ferritin ratio (87.9%). The sTfR levels (r = -0.359; = 0.003) and sTfR/log ferritin ratio (r = -0.375; = 0.002) were negatively correlated with Hb levels. There was no correlation between the levels of hepcidin and Hb (r = -0.140; p = 0.264), but there was a positive correlation between ferritin and Hb levels (r = 0.350; p = 0.004).
This study showed a correlation between iron status and Hb levels in overweight and obese women of childbearing age. All the women had erythropoiesis with iron deficiency anaemia. We recommend that overweight and obese women undergo further iron parameters for the detection of early anaemia. In this group, the consumption of foods that enhance iron absorption, such as ascorbic acid, should be encouraged.
超重被认为是贫血的一个危险因素。然而，超重和肥胖人群贫血发生的潜在机制仍不清楚。本研究分析了育龄超重和肥胖女性的铁状态（可溶性转铁蛋白受体[sTfR]/铁蛋白对数比值）和铁调素水平与血红蛋白（Hb）水平的相关性。
在这项横断面研究中，我们招募了66名年龄在20 - 29岁、体重指数≥23kg/m²的女性。我们收集了知情同意书、人口统计学特征、问卷调查回复、人体测量和实验室检查值等数据。进行Spearman相关性检验以确定相关性。
铁蛋白和sTfR的平均水平分别为10.2±8.12和22.2±7.96ng/ml，平均sTfR/铁蛋白对数比值为29.3±17.65nmol/L。铁调素的平均水平为9.0±3.05ng/ml。总体而言，75.8%的受试者铁蛋白水平低，sTfR水平高（51.5%），sTfR/铁蛋白对数比值高（87.9%）。sTfR水平（r = -0.359；P = 0.003）和sTfR/铁蛋白对数比值（r = -0.375；P = 0.002）与Hb水平呈负相关。铁调素水平与Hb之间无相关性（r = -0.140；P = 0.264），但铁蛋白与Hb水平呈正相关（r = 0.350；P = 0.004）。
本研究表明育龄超重和肥胖女性的铁状态与Hb水平之间存在相关性。所有女性均存在缺铁性贫血的红细胞生成。我们建议超重和肥胖女性进一步检查铁参数以检测早期贫血。在这一群体中，应鼓励食用增强铁吸收的食物，如抗坏血酸。
