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石榴（Punica granatum L.）果皮提取物及其馏分的抗流感病毒活性和酚类含量

Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L.) Peel Extract and Fractions.

作者信息

Moradi Mohammad-Taghi, Karimi Ali, Shahrani Mehrdad, Hashemi Leila, Ghaffari-Goosheh Mohammad-Saleh

机构信息

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

Avicenna J Med Biotechnol. 2019 Oct-Dec;11(4):285-291.

PMID:31908736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6925405/
Abstract

BACKGROUND

Influenza virus, associated with high level of morbidity and mortality, has been recently considered a public health concern while the choices for the control and treatment of the disease are limited. The present study was conducted to evaluate activity of pomegranate peel extract and its fractions against virus .

METHODS

In this research, ethyl alcohol extract of pomegranate peel was prepared and subjected to fractionation with different polarities. The potential anti-influenza A virus activity of the extract and fractions was assessed using Cytopathic Effect (CPE) reduction assay, Hemagglutinin Assay (HA), and 50% Tissue Culture Infectious Doses (TCID) method in Madin-Darby Canine Kidney (MDCK) cells.

RESULTS

The crude pomegranate peel extract and its n-butanol and ethyl acetate fractions had the highest inhibitory effect against influenza A virus with IC value of 6.45, 6.07 and 5.6 in MDCK cells, respectively. Our results also showed that, the production of virus was significantly reduced upon treatment with crude extract, n-butanol and ethyl acetate fractions in a dose-dependent manner (p<0.05).

CONCLUSION

Based on our results, the ethyl alcohol extract and its polar fractions of pomegranate peel can inhibit influenza A virus replication . Therefore, further characterization of its active ingredients and the mechanism of action should be carried out.

摘要

背景

流感病毒与高发病率和死亡率相关，最近已成为公共卫生关注的问题，而该疾病的控制和治疗选择有限。本研究旨在评估石榴皮提取物及其馏分对病毒的活性。

方法

在本研究中，制备了石榴皮乙醇提取物并进行不同极性的分馏。使用细胞病变效应（CPE）减少试验、血凝素试验（HA）和50%组织培养感染剂量（TCID）方法，在犬肾传代细胞（MDCK）中评估提取物及其馏分对甲型流感病毒的潜在活性。

结果

石榴皮粗提物及其正丁醇和乙酸乙酯馏分对甲型流感病毒具有最高的抑制作用，在MDCK细胞中的IC值分别为6.45、6.07和5.6。我们的结果还表明，用粗提物、正丁醇和乙酸乙酯馏分处理后，病毒产量以剂量依赖性方式显著降低（p<0.05）。

结论

根据我们的结果，石榴皮乙醇提取物及其极性馏分可抑制甲型流感病毒复制。因此，应进一步对其活性成分及其作用机制进行表征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/703f780f409f/AJMB-11-285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/cd7acdb24dd0/AJMB-11-285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/47fb7531b626/AJMB-11-285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/703f780f409f/AJMB-11-285-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/cd7acdb24dd0/AJMB-11-285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/47fb7531b626/AJMB-11-285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de5/6925405/703f780f409f/AJMB-11-285-g003.jpg

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