Sánchez Juménez Cecilia, Pacheco Moisés Fermín Paul, Cano M E, Nava Andrade Karina, Briones Torres Ana Laura, Carbajal Arízaga Gregorio Guadalupe
Departamento de Química, Universidad de Guadalajara, Marcelino García Barragán 1421, colonia Olímpica, C.P. 44430, Guadalajara, Jalisco, Mexico.
Centro Universitario de la Ciénega, Universidad de Guadalajara, Avenida Universidad 1115, colonia Linda Vista, C.P. 47820, Ocotlán, Jalisco, Mexico.
Heliyon. 2019 Dec 31;6(1):e03111. doi: 10.1016/j.heliyon.2019.e03111. eCollection 2020 Jan.
Zinc/aluminum layered double hydroxide (LDH) particles were prepared by alkaline precipitation in the presence of dysprosium and dysprosium/gadolinium cations. The particles formed were stable against exchange reactions with folate or glucuronate ions since these organic ions exclusively functionalized the external surface of the layered double hydroxides. While the dysprosium derivatives reached magnetization susceptibilities between 2.06 × 10 and 2.20 × 10 cm/g, the samples simultaneously containing dysprosium and gadolinium decreased to a range between 1.08 × 10 and 1.73 × 10 cm/g. This last sample was tested as a magnetic resonance imaging contrast agent and demonstrated a reduction in T1 and T2 relaxation times in a linear dependence with the LDH concentration. The oxidative stress assays in rat liver mitochondria demonstrated the low toxicity of the composition simultaneously containing dysprosium and gadolinium as well as the functionalization product with glucuronate ions, suggesting the potential of these particles to design alternative MRI contrast agents.
锌/铝层状双氢氧化物（LDH）颗粒是在镝和镝/钆阳离子存在的情况下通过碱性沉淀法制备的。形成的颗粒对与叶酸或葡萄糖醛酸离子的交换反应具有稳定性，因为这些有机离子仅使层状双氢氧化物的外表面功能化。虽然镝衍生物的磁化率在2.06×10至2.20×10 cm/g之间，但同时含有镝和钆的样品降至1.08×10至1.73×10 cm/g的范围。最后一个样品作为磁共振成像造影剂进行了测试，并显示出T1和T2弛豫时间的缩短与LDH浓度呈线性相关。大鼠肝线粒体中的氧化应激试验表明，同时含有镝和钆的组合物以及与葡萄糖醛酸离子的功能化产物具有低毒性，表明这些颗粒具有设计替代MRI造影剂的潜力。
