Department of Radiology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210029, China.
Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, 210029, China.
Brain Imaging Behav. 2020 Dec;14(6):2559-2568. doi: 10.1007/s11682-019-00208-2.
Depression is the most common non-motor symptom accompanying Parkinson's disease (PD) with high prevalence but unclear pathophysiological mechanism. Relatively little is known about the topological patterns of white matter structural networks in depressed patients with PD. In this study, we used diffusion-tensor imaging (DTI) and graph theory approaches to explore the brain structural connectome in non-depressed patients with PD (n = 47), depressed patients with PD (n = 20) and healthy controls (n = 46). All three groups exhibited small-world topology. Compared with healthy controls, non-depressed patients with PD and depressed patients with PD showed a significant reduction of network efficiency in the cortico-subcortical circuits. Moreover, depressed patients with PD exhibited higher network efficiency in fronto-limbic system, compared to non-depressed patients with PD. To sum up, our data indicated a disrupted integrity in the large-scale brain systems in depressed patients with PD patients. The structural connectome provided a basis for functional alterations in depressed patients with PD that may advance our current understanding of pathophysiological mechanism underlying Parkinson's disease.
抑郁症是帕金森病（PD）最常见的非运动症状，其患病率较高，但发病机制尚不清楚。目前对于伴发抑郁症的 PD 患者大脑白质结构网络的拓扑模式知之甚少。在这项研究中，我们使用弥散张量成像（DTI）和图论方法来探索非抑郁性 PD 患者（n=47）、伴抑郁 PD 患者（n=20）和健康对照组（n=46）的脑结构连接组。三组均表现出小世界拓扑结构。与健康对照组相比，非抑郁性 PD 患者和抑郁性 PD 患者的皮质-皮质下回路的网络效率显著降低。此外，与非抑郁性 PD 患者相比，抑郁性 PD 患者的额-边缘系统的网络效率更高。总之，我们的数据表明，伴发抑郁症的 PD 患者的大脑大系统完整性受损。结构连接组为伴发抑郁症 PD 患者的功能改变提供了基础，这可能有助于我们进一步理解帕金森病的发病机制。
