Guangdong Provincial Key Laboratory of Marine Biotechnology, College of Sciences, Shantou University, Shantou, Guangdong, China.
Faculty of Marine Sciences, Lasbela University, Uthal, Pakistan.
PLoS One. 2020 Jan 7;15(1):e0227308. doi: 10.1371/journal.pone.0227308. eCollection 2020.
Seaweed polyphenols and polysaccharide plays a broad range of biological activity. The objective of the present study was to study and compare the skin protection activity of fucoidan rich polysaccharide extract (SPS) and polyphenol-rich extract (SPP) from the seaweed Sargassum vachellianum. The skin protection activity was analyzed based on their ability to scavenge free radicals such as hydrogen peroxide and hydroxyl radicals, UV absorption potential, tyrosinase inhibition, moisture preservation, and antibacterial activity. From the results, both SPP and SPS protects the skin from UV damage. SPP showed good free radical scavenging ability, antimicrobial activity against E.coli and S. aureus and effectively absorbed the UVB and UVA rays whereas SPS hardly absorbs the UVA and UVB rays and showed weak free radical scavenging ability and no antimicrobial activity. SPS showed considerable inhibition on tyrosinase (51.21%) and had better moisture absorption (52.1%) and retention (63.24%) abilities than SPP. The results specified that both SPS and SPP have balancing potential on skin protection and suitable combinations of both could act as an active ingredient in cosmetics.
海藻多酚和多糖具有广泛的生物活性。本研究旨在研究和比较来自马尾藻 Sargassum vachellianum 的富含褐藻多糖提取物 (SPS) 和富含多酚提取物 (SPP) 的皮肤保护活性。通过其清除过氧化氢和羟自由基等自由基的能力、紫外线吸收潜力、酪氨酸酶抑制活性、保湿和抗菌活性来分析皮肤保护活性。结果表明，SPP 和 SPS 都能保护皮肤免受紫外线伤害。SPP 表现出良好的自由基清除能力、对大肠杆菌和金黄色葡萄球菌的抗菌活性，并能有效吸收 UVB 和 UVA 射线，而 SPS 几乎不吸收 UVA 和 UVB 射线，自由基清除能力较弱，无抗菌活性。SPS 对酪氨酸酶的抑制率为 51.21%，保湿率(52.1%)和保持率(63.24%)均优于 SPP。结果表明，SPS 和 SPP 均具有平衡的皮肤保护潜力，两者的合适组合可作为化妆品中的活性成分。
