Feng Yao, Yang Dian-Song, Tang Hai-Bo, Ding Yuan-Sheng, Li Xiao-Guang
First Unit of Dental Pulp Disease Department.
Department of Radiation.
Medicine (Baltimore). 2020 Jan;99(2):e18338. doi: 10.1097/MD.0000000000018338.
This study aims to explore the effectiveness of vitamin D for the management of adult patients with gingivitis.
We will perform a comprehensive search from the following electronic databases: Cochrane Library, PUBMED, EMBASE, AMED, CINAHL, WANGFANG, VIP, CBM, and China National Knowledge Infrastructure. All databases will be searched from their inceptions to the present without language limitation. We will also search for unpublished data to avoid missing more potential studies. Two authors will carry out study selection, data extraction, and methodological quality evaluation, respectively. RevMan 5.3 software will be utilized for statistical analysis.
This study will summarize the up-to-date evidence about the anti-inflammatory effect of vitamin D for the management of adult patients with gingivitis through assessing modified gingival, gingival bleeding indices, inflammatory factors, plaque, quality of life, and any adverse events.
This study may provide helpful evidence of vitamin D for the management of adult patients with gingivitis for clinical practice.
PROSPERO CRD42019156561.
本研究旨在探讨维生素D对成人牙龈炎患者的治疗效果。
我们将从以下电子数据库进行全面检索：Cochrane图书馆、PUBMED、EMBASE、AMED、CINAHL、万方、维普、中国生物医学文献数据库和中国知网。所有数据库将从建库至当前进行检索，无语言限制。我们还将搜索未发表的数据，以避免遗漏更多潜在研究。两位作者将分别进行研究筛选、数据提取和方法学质量评估。将使用RevMan 5.3软件进行统计分析。
本研究将通过评估改良牙龈指数、牙龈出血指数、炎症因子、菌斑、生活质量和任何不良事件，总结关于维生素D对成人牙龈炎患者抗炎作用的最新证据。
本研究可能为维生素D用于成人牙龈炎患者的临床治疗提供有用的证据。
PROSPERO CRD42019156561
