Kosmachev A B, Kosmacheva I M, Chigareva S M
Farmakol Toksikol. 1988 Sep-Oct;51(5):86-9.
The comparative study revealed significant differences in the effects of antimuscarinics on the outcome of intoxication in animals induced by direct and indirect cholinomimetics. The doses of the agents possessing equal choline blocking activity provide different levels of protection at chlorophos-induced intoxication of animals that is not observed at carbacholine-induced intoxication. The differences in the effects of direct and indirect cholinomimetics were used for the elaboration of the methodical approach that made it possible to formulate a hypothesis about the ambivalent character of the action of antimuscarinics. The hypothesis implies that the protective activity of the agents at intoxication by organophosphorus compounds is determined by the ratio of their effects on pre- and postsynaptic cholinoreceptors.
比较研究表明，抗毒蕈碱药物对直接和间接拟胆碱药诱导的动物中毒结局的影响存在显著差异。具有同等胆碱阻断活性的药物剂量，在毒死蜱诱导的动物中毒时提供不同程度的保护，而在氨甲酰胆碱诱导的中毒中未观察到这种情况。直接和间接拟胆碱药作用的差异被用于制定一种方法学方法，这使得有可能形成关于抗毒蕈碱药物作用矛盾特性的假说。该假说认为，这些药物对有机磷化合物中毒的保护活性取决于它们对突触前和突触后胆碱能受体作用的比例。
