Leon Judah Blackmore Sleep Disorders Program, UBC Hospital, Vancouver, BC, Canada.
Respiratory Divisions, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
COPD. 2020 Feb;17(1):40-48. doi: 10.1080/15412555.2019.1695247. Epub 2020 Jan 10.
Small studies have suggested that patients with chronic obstructive pulmonary disease (COPD) have poor sleep quality. Our aim was to examine the prevalence of subjective sleep-related complaints and predictors of poor sleep quality in a large community-based COPD cohort. We analyzed cross-sectional data on sleep questionnaire responses from the Canadian Cohort of Obstructive Lung Disease (CanCOLD) study, a population-based, prospective longitudinal cohort study across Canada. The cohort comprises a COPD group and two matched non-COPD (never-smokers and ever-smokers) groups. Sleep-related symptoms were assessed using questionnaires including Pittsburgh Sleep Quality Index (PSQI). A total score of PSQI > 5 is indicative of poor sleep quality. Health-related quality of life measures and the presence of mood disturbance were assessed using Short Form-36™ Health Survey (SF-36) multi-item questionnaires and Hospital Anxiety and Depression Scale (HADS), respectively. Predictors of poor sleep quality were analyzed using multivariable logistic regression analysis. Of the 1123 subjects, 263 were healthy controls, 323 at-risk controls, and 537 had COPD (297 had mild, 240 with moderate to severe disease). The mean PSQI score was not significantly different between groups. COPD patients with poor sleep quality had lower diffusion capacity, higher HADS anxiety and depression scores and lower SF-36 mental and physical component summary scores than COPD patients classified as good sleepers. The presence of restless legs and obstructive sleep apnea symptoms, waist circumference, predicted diffusion capacity and HADS anxiety and depression scores were identified as independent predictors of poor sleep quality.
一些小型研究表明，慢性阻塞性肺疾病（COPD）患者的睡眠质量较差。我们的目的是在一个大型基于社区的 COPD 队列中研究主观睡眠相关投诉的流行率和睡眠质量差的预测因素。我们分析了加拿大阻塞性肺病队列研究（CanCOLD）的睡眠问卷反应的横断面数据，这是一项基于人群的前瞻性纵向队列研究，在加拿大各地进行。该队列包括 COPD 组和两个匹配的非 COPD 组（从不吸烟者和曾吸烟者）。使用包括匹兹堡睡眠质量指数（PSQI）在内的问卷评估与睡眠相关的症状。PSQI 总分> 5 表示睡眠质量差。使用短格式 36 健康调查（SF-36）多项目问卷和医院焦虑和抑郁量表（HADS）评估健康相关生活质量措施和情绪障碍的存在。使用多变量逻辑回归分析来分析睡眠质量差的预测因素。在 1123 名受试者中，263 名是健康对照者，323 名是高危对照者，537 名患有 COPD（297 名轻度，240 名中度至重度）。PSQI 评分在各组之间无显著差异。与被归类为睡眠良好的 COPD 患者相比，睡眠质量差的 COPD 患者的弥散能力较低，HADS 焦虑和抑郁评分较高，SF-36 心理和生理成分综合评分较低。不安腿和阻塞性睡眠呼吸暂停症状的存在、腰围、预测的弥散能力以及 HADS 焦虑和抑郁评分被确定为睡眠质量差的独立预测因素。
