Feng Vivian, Tumati Shankar, Wang Ruoding, Bawa Kritleen K, Gallagher Damien, Herrmann Nathan, Marzolini Susan, Oh Paul, Andreazza Ana, Lanctôt Krista L
Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada.
Brain Sci. 2022 Aug 12;12(8):1070. doi: 10.3390/brainsci12081070.
(1) Sleep disorders are prevalent in coronary artery disease (CAD) patients and predict cardiac events and prognosis. While increased oxidative stress (OS) has been associated with sleep disorders, less is known about its relationship with sleep quality. Similarly, little is known of how this relationship might change with exercise, which can improve sleep quality. Factors of sleep quality, such as sleep duration and disturbances, are also important as they predict cardiovascular diseases better than a global score alone. This study investigated whether OS was associated with self-rated sleep quality and its factors before and after completing a 24-week exercise intervention. (2) Methods: CAD patients undergoing an exercise program were recruited. OS was measured at baseline by the concentrations of early- (lipid hydroperoxides, LPH) and late-stage (8-isoprostane, 8-ISO) lipid peroxidation products and their ratio. Sleep quality was measured by the self-reported Pittsburgh Sleep Quality Index (PSQI) instrument at baseline and termination. Three sleep factors-perceived sleep quality, sleep efficiency, and daily disturbances-were derived from the PSQI. (3) Results: Among CAD patients ( = 113, 85.0% male, age = 63.7 ± 6.4 years, global PSQI = 5.8 ± 4.0), those with poor sleep (PSQI ≥ 5) had higher baseline 8-ISO levels (F(1, 111) = 6.212, = 0.014, η = 0.053) compared to those with normal sleep. Concentrations of LPH (F(1, 105) = 0.569, = 0.453, η = 0.005) and 8-ISO/LPH ratios (F(1, 105) = 2.173, = 0.143, η = 0.020) did not differ between those with poor sleep and normal sleep. Among factors, perceived sleep quality was associated with 8-ISO and 8-ISO/LPH, and daily disturbances were associated with 8-ISO. (4) Conclusions: A marker of late-stage lipid peroxidation is elevated in CAD patients with poor sleep and associated with daily disturbances, but not with other factors or with sleep quality and its factors after exercise intervention.
（1）睡眠障碍在冠状动脉疾病（CAD）患者中很普遍，并且可预测心脏事件和预后。虽然氧化应激（OS）增加与睡眠障碍有关，但其与睡眠质量的关系却鲜为人知。同样，对于这种关系如何随运动而变化也知之甚少，而运动可以改善睡眠质量。睡眠质量的因素，如睡眠时间和干扰因素，也很重要，因为它们比单一的总体评分更能预测心血管疾病。本研究调查了在完成一项为期24周的运动干预前后，氧化应激是否与自我评定的睡眠质量及其因素相关。（2）方法：招募正在进行运动计划的CAD患者。在基线时通过早期（脂质氢过氧化物，LPH）和晚期（8-异前列腺素，8-ISO）脂质过氧化产物的浓度及其比值来测量氧化应激。在基线和结束时通过自我报告的匹兹堡睡眠质量指数（PSQI）工具来测量睡眠质量。从PSQI中得出三个睡眠因素——感知睡眠质量、睡眠效率和日常干扰因素。（3）结果：在CAD患者中（n = 113，85.0%为男性，年龄 = 63.7 ± 6.4岁，总体PSQI = 5.8 ± 4.0），与睡眠正常的患者相比，睡眠差（PSQI≥5）的患者基线8-ISO水平更高（F(1, 1×11) = 6.212，P = 0.014，η = 0.053）。睡眠差和睡眠正常的患者之间，LPH浓度（F(1, 1×05) = 0.569，P = 0.453，η = 0.005）和8-ISO/LPH比值（F(1, 1×05) = 2.173，P = 0.143，η = 0.020）没有差异。在这些因素中，感知睡眠质量与8-ISO和8-ISO/LPH相关，日常干扰因素与8-ISO相关。（4）结论：晚期脂质过氧化标志物在睡眠差的CAD患者中升高，且与日常干扰因素相关，但与其他因素或运动干预后的睡眠质量及其因素无关。
