Ghaedi Maryam, Takei Fumio
Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
the Department of Pathology and Laboratory Medicine, University of British Columbia (UBC), Vancouver, British Columbia, Canada; Terry Fox Laboratory, B.C. Cancer, Vancouver, British Columbia, Canada.
J Allergy Clin Immunol. 2021 May;147(5):1549-1560. doi: 10.1016/j.jaci.2021.03.009.
Innate lymphoid cells (ILCs) mainly reside at barrier surfaces and regulate tissue homeostasis and immunity. ILCs are divided into 3 groups, group 1 ILCs, group 2 ILCs, and group 3 ILC3, on the basis of their similar effector programs to T cells. The development of ILCs from lymphoid progenitors in adult mouse bone marrow has been studied in detail, and multiple ILC progenitors have been characterized. ILCs are mostly tissue-resident cells that develop in the perinatal period. More recently, ILC progenitors have also been identified in peripheral tissues. In this review, we discuss the stepwise transcription factor-directed differentiation of mouse ILC progenitors into mature ILCs, the critical time windows in ILC development, and the contribution of bone marrow versus tissue ILC progenitors to the pool of mature ILCs in tissues.
固有淋巴细胞（ILCs）主要驻留在屏障表面，调节组织稳态和免疫。根据与T细胞相似的效应程序，ILCs可分为3组，即1型ILCs、2型ILCs和3型ILC3。成年小鼠骨髓中淋巴祖细胞向ILCs的发育已得到详细研究，多种ILC祖细胞已被鉴定。ILCs大多是在围产期发育的组织驻留细胞。最近，外周组织中也发现了ILC祖细胞。在本综述中，我们讨论了小鼠ILC祖细胞向成熟ILCs的逐步转录因子导向分化、ILC发育中的关键时间窗口，以及骨髓与组织ILC祖细胞对组织中成熟ILCs库的贡献。
