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宫颈癌的头皮及颅骨转移——一种罕见情况。

Scalp and skull bone metastasis in cervical carcinoma-a rare entity.

作者信息

Díaz José Fernando Robles, Zelaya Adela Heredia, Rosas Alicia Milagros Avalos

机构信息

National Institute of Neoplastic Diseases, Lima 34, Av. Angamos Este 2520 Surquillo, Lima, Peru.

出版信息

Ecancermedicalscience. 2019 Oct 17;13:969. doi: 10.3332/ecancer.2019.969. eCollection 2019.

DOI:10.3332/ecancer.2019.969
PMID:31921340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6834395/
Abstract

Cervical cancer is the second most common cancer in women worldwide and the first in Peru; however, metastasis to the cranial scalp is extremely rare. We present the case of a 41-year-old woman diagnosed with cervical cancer IIIB, who received treatment based on concurrent pelvic radiotherapy with chemotherapy followed by brachytherapy at the primary level with complete response, developing, at 18 months, a metastatic lesion at the scalp level without evidence of recurrence in the cervix. With the rapid growth of the metastatic lesion leading to the destruction of the cranial cap, the meninges can be observed directly, without presenting to the neurological clinic.

摘要

宫颈癌是全球女性中第二常见的癌症,在秘鲁则是第一常见的癌症;然而,转移至头皮极为罕见。我们报告一例41岁女性,被诊断为IIIB期宫颈癌,接受了盆腔同步放化疗,随后进行了原发灶近距离放疗,治疗后完全缓解,18个月时头皮出现转移灶,宫颈未见复发迹象。随着转移灶迅速生长导致颅盖破坏,可以直接观察到脑膜,且患者未前往神经科就诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/21a067289891/can-13-969fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/1535f2c24e51/can-13-969fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/ce662cee3a3c/can-13-969fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/2982a35b5a31/can-13-969fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/bde5e381ee24/can-13-969fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/e6f99eb3f0f3/can-13-969fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/21a067289891/can-13-969fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/1535f2c24e51/can-13-969fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/ce662cee3a3c/can-13-969fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/2982a35b5a31/can-13-969fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/bde5e381ee24/can-13-969fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/e6f99eb3f0f3/can-13-969fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd43/6834395/21a067289891/can-13-969fig6.jpg

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本文引用的文献

1
Unusual Metastasis from Carcinoma Cervix.宫颈癌的罕见转移
J Obstet Gynaecol India. 2016 Oct;66(5):358-62. doi: 10.1007/s13224-015-0692-y. Epub 2015 May 9.
2
Scalp, skull and brain metastasis of squamous cell carcinoma of the cervix--a rare entity.子宫颈鳞状细胞癌的头皮、颅骨和脑转移——一种罕见情况。
Br J Neurosurg. 2013 Aug;27(4):519-20. doi: 10.3109/02688697.2013.764971. Epub 2013 Feb 14.
3
Cervical cancer metastasis to the scalp: case report and literature review.宫颈癌转移至头皮:病例报告及文献综述
Eur J Gynaecol Oncol. 2010;31(2):217-8.
4
Bulky scalp metastasis and superior sagittal sinus thrombosis from a cervical adenocarcinoma: an unusual case.一例罕见的宫颈腺癌导致的巨大头皮转移瘤及上矢状窦血栓形成病例
J Med Imaging Radiat Oncol. 2008 Feb;52(1):91-4. doi: 10.1111/j.1440-1673.2007.01918.x.
5
Cervical cancer metastasis to the scalp presenting as alopecia neoplastica.宫颈癌转移至头皮表现为肿瘤性脱发。
Int J Dermatol. 2007 Feb;46(2):188-9. doi: 10.1111/j.1365-4632.2007.03183.x.
6
Worldwide burden of gynaecological cancer: the size of the problem.全球妇科癌症负担:问题的规模
Best Pract Res Clin Obstet Gynaecol. 2006 Apr;20(2):207-25. doi: 10.1016/j.bpobgyn.2005.10.007. Epub 2005 Dec 13.
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Scalp metastasis in carcinoma of the uterine cervix--a rare entity.子宫颈癌的头皮转移——一种罕见情况。
Gynecol Oncol. 2002 Dec;87(3):310-2. doi: 10.1006/gyno.2002.6829.
8
Scalp metastasis from squamous cell carcinoma of the cervix.宫颈鳞状细胞癌的头皮转移
Int J Gynecol Cancer. 2001 May-Jun;11(3):244-6. doi: 10.1046/j.1525-1438.2001.00074.x.
9
Cutaneous metastases to the scalp from carcinoma of the uterine cervix.
Arch Dermatol. 1983 Apr;119(4):275-6.