神经影像学数据表明，肌萎缩侧索硬化症、阿尔茨海默病和健康衰老过程中，内侧颞叶存在不同的特征。
Neuroimaging data indicate divergent mesial temporal lobe profiles in amyotrophic lateral sclerosis, Alzheimer's disease and healthy aging.
作者信息
Christidi Foteini, Karavasilis Efstratios, Rentzos Michail, Velonakis Georgios, Zouvelou Vasiliki, Xirou Sofia, Argyropoulos Georgios, Papatriantafyllou Ioannis, Pantolewn Varvara, Ferentinos Panagiotis, Kelekis Nikolaos, Seimenis Ioannis, Evdokimidis Ioannis, Bede Peter
机构信息
First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece.
Second Department of Radiology, General University Hospital "Attikon", National and Kapodistrian University of Athens, Greece.
出版信息
Data Brief. 2019 Dec 19;28:104991. doi: 10.1016/j.dib.2019.104991. eCollection 2020 Feb.
A prospective, standardised neuroimaging protocol was implemented to characterise mesial temporal lobe pathology in amyotrophic lateral sclerosis, Alzheimer's disease and healthy controls focusing on the evaluation of interconnected white and grey matter structures. "Hippocampal pathology in Amyotrophic Lateral Sclerosis: selective vulnerability of subfields and their associated projections" [1]. High-resolution diffusion tensor and structural imaging data were acquired on a 3 T MRI platform using standardised sequence parameters. The integrity of the fornix and the perforant pathway was assessed by tractography, to provide fractional anisotropy, axial diffusivity and radial diffusivity measures. Quantitative structural imaging was used to estimate the total intracranial volume, total hippocampal volumes and hippocampal subfield volumes for each participant. Raw white- and grey-matter measures, demographic and clinical data are available online at 'Mendeley Data'. Amyotrophic lateral sclerosis and Alzheimer's disease exhibit divergent hippocampal profiles.
实施了一项前瞻性、标准化的神经成像方案，以表征肌萎缩侧索硬化症、阿尔茨海默病和健康对照者的内侧颞叶病理情况，重点评估相互连接的白质和灰质结构。“肌萎缩侧索硬化症中的海马病理：亚区及其相关投射的选择性易损性”[1]。使用标准化序列参数在3T MRI平台上获取高分辨率扩散张量和结构成像数据。通过纤维束成像评估穹窿和穿通通路的完整性，以提供分数各向异性、轴向扩散率和径向扩散率测量值。定量结构成像用于估计每位参与者的总颅内体积、海马总体积和海马亚区体积。原始白质和灰质测量值、人口统计学和临床数据可在“Mendeley数据”网站在线获取。肌萎缩侧索硬化症和阿尔茨海默病表现出不同的海马特征。
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