包括载脂蛋白Eε4在内的基因特征会增加单纯疱疹相关性阿尔茨海默病的风险。
A genetic signature including apolipoprotein Eε4 potentiates the risk of herpes simplex-associated Alzheimer's disease.
作者信息
Lopatko Lindman Karin, Weidung Bodil, Olsson Jan, Josefsson Maria, Kok Eloise, Johansson Anders, Eriksson Sture, Hallmans Göran, Elgh Fredrik, Lövheim Hugo
机构信息
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
出版信息
Alzheimers Dement (N Y). 2019 Nov 4;5:697-704. doi: 10.1016/j.trci.2019.09.014. eCollection 2019.
INTRODUCTION
Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.
METHODS
Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age- and sex-matched controls, were analyzed for anti-HSV1 immunoglobulin (Ig) G with enzyme-linked immunosorbent assays (ELISAs). genotype and nine other selected risk genes for AD were extracted from a genome-wide association study analysis by deCODE genetics, Reykjavik, Iceland.
RESULTS
The interaction between 4 heterozygosity (24 or 3/4) and anti-HSV1 IgG carriage increased the risk of AD (OR 4.55, = .02). A genetic risk score based on the nine AD risk genes also interacted with anti-HSV1 IgG for the risk of developing AD (OR 2.35, = .01).
DISCUSSION
The present findings suggest that the 4 allele and other AD genetic risk factors might potentiate the risk of HSV1-associated AD.
引言
1型单纯疱疹病毒（HSV1）与遗传易感性相结合，此前已被认为与阿尔茨海默病（AD）的发病机制有关。
方法
采用酶联免疫吸附测定（ELISA）分析了360例AD患者（平均在诊断前9.6年采集血浆）及其年龄和性别匹配的对照者血浆中的抗HSV1免疫球蛋白（Ig）G。从冰岛雷克雅未克的deCODE遗传学公司进行的全基因组关联研究分析中提取了AD的4基因型和其他9个选定的风险基因。
结果
4杂合性（24或3/4）与抗HSV1 IgG携带之间的相互作用增加了AD风险（比值比4.55，P = 0.02）。基于9个AD风险基因的遗传风险评分也与抗HSV1 IgG相互作用，影响患AD的风险（比值比2.35，P = 0.01）。
讨论
目前的研究结果表明，4等位基因和其他AD遗传风险因素可能会增加HSV1相关AD的风险。
Zotero 插件