与抗单纯疱疹病毒、巨细胞病毒抗体相关的血浆淀粉样蛋白-β及…… （原文最后似乎不完整）
Plasma Amyloid-β in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and .
作者信息
Lopatko Lindman Karin, Weidung Bodil, Olsson Jan, Josefsson Maria, Johansson Anders, Eriksson Sture, Hallmans Göran, Elgh Fredrik, Lövheim Hugo
机构信息
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden.
出版信息
J Alzheimers Dis Rep. 2021 Apr 6;5(1):229-235. doi: 10.3233/ADR-210008.
BACKGROUND
Amyloid-β (Aβ), the key constituent of Alzheimer's disease (AD) plaques, has antimicrobial properties.
OBJECTIVE
To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and .
METHODS
Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ and Aβ concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti- IgG. Follow-up samples were available for 150 of the cases.
RESULTS
Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti- IgG did not correlate with concentrations of Aβ or Aβ in cases or controls.
CONCLUSION
Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.
背景
淀粉样β蛋白（Aβ）是阿尔茨海默病（AD）斑块的关键成分，具有抗菌特性。
目的
研究血浆Aβ与抗AD相关病原体单纯疱疹病毒（HSV）、巨细胞病毒（CMV）抗体之间的关联。
方法
采用Luminex xMAP技术和INNOBIA血浆Aβ形式检测法，对339例AD患者（平均在诊断前9.4年（±4.00）采集）及其匹配对照的血浆进行Aβ和Aβ浓度分析。采用酶联免疫吸附测定法分析抗HSV免疫球蛋白（Ig）G、抗HSV1 IgG、抗HSV2 IgG、抗CMV IgG和抗IgG。150例患者有随访样本。
结果
病例组和对照组中抗HSV1 IgG、抗HSV2 IgG、抗CMV IgG和抗IgG的存在及水平与Aβ或Aβ浓度均无相关性。
结论
血浆Aβ水平与抗不同AD相关病原体的抗体无关。
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