Liu Zheng-Gang, Jiao Delong
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute; National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892.
Cell Stress. 2019 Dec 19;4(1):1-8. doi: 10.15698/cst2020.01.208.
Necroptosis, known as programmed necrosis, is a form of caspase-independent, finely regulated cell death with necrotic morphology. Tumor necrosis, foci of necrotic cell death, occurs in advanced solid tumors and is often associated with poor prognosis of cancer patients. While it is well documented that apoptosis plays a key role in tumor regression and the inactivation of apoptosis is pivotal to tumor development, the role of necroptosis in tumorigenesis is still not fully understood as recent studies have reported both tumor-promoting and tumor-suppressing effects of necroptosis. In this short review, we will discuss some recent studies about the role of necroptosis in tumorigenesis and speculate the implications of these findings in future research and potential novel cancer therapy targeting necroptosis.
坏死性凋亡，即程序性坏死，是一种不依赖半胱天冬酶的、受到精细调控的细胞死亡形式，具有坏死形态。肿瘤坏死，即坏死性细胞死亡灶，发生于晚期实体瘤中，且常与癌症患者的不良预后相关。虽然有充分的文献记载凋亡在肿瘤消退中起关键作用，且凋亡失活对肿瘤发展至关重要，但坏死性凋亡在肿瘤发生中的作用仍未完全明确，因为最近的研究既报道了坏死性凋亡的促肿瘤作用，也报道了其抑肿瘤作用。在这篇简短的综述中，我们将讨论一些关于坏死性凋亡在肿瘤发生中作用的最新研究，并推测这些发现对未来研究以及针对坏死性凋亡的潜在新型癌症治疗的意义。
