小鼠小肠中（自发）免疫球蛋白产生随年龄的变化情况。
Background (spontaneous) immunoglobulin production in the murine small intestine as a function of age.
作者信息
Van der Heijden P J, Bianchi A T, Stok W, Bokhout B A
机构信息
Department of Immunology, Central Veterinary Institute, Leylystad, The Netherlands.
出版信息
Immunology. 1988 Oct;65(2):243-8.
The development of the intestinal B-cell compartment in C3H/He mice was studied as a function of age by quantification of the number of intestinal immunoglobulin-secreting cells (Ig-SC). Before and at weaning, the number of Ig-SC in the small intestine (SI) was below 10(3) Ig-SC per SI. During the first few weeks after weaning, this number rose steeply and continued to rise until the mice were about 48 weeks old, when a maximum of more than 25 x 10(6) Ig-SC per SI was found. After 1 year of age the number of Ig-SC decreased. At all ages, the great majority of Ig-SC in the SI produced IgA. The increase of the number of IgA-SC in the SI after weaning is reflected in the amount of IgA in intestinal secretions measured by ELISA. The number of Ig-SC in the SI was compared with the number of Ig-SC found in spleen, bone marrow, Peyer's patches and mesenteric lymph nodes. Striking differences were observed between the SI and the other organs tested in total number, isotype distribution and kinetics of the increase of Ig-SC during ontogeny. These differences are discussed in relation to the regulation of the immune response in the SI and the migration patterns of lymphocytes in mucosal tissues.
通过对肠道免疫球蛋白分泌细胞（Ig-SC）数量进行定量分析，研究了C3H/He小鼠肠道B细胞区室随年龄的发育情况。断奶前及断奶时，小肠（SI）中Ig-SC的数量低于每SI 10³个Ig-SC。断奶后的最初几周内，这一数量急剧上升，并持续上升直至小鼠约48周龄，此时每SI发现的Ig-SC数量最多超过25×10⁶个。1岁以后，Ig-SC的数量减少。在所有年龄段，SI中绝大多数Ig-SC产生IgA。断奶后SI中IgA-SC数量的增加反映在通过ELISA测量的肠道分泌物中IgA的含量上。将SI中Ig-SC的数量与在脾脏、骨髓、派尔集合淋巴结和肠系膜淋巴结中发现的Ig-SC数量进行了比较。在SI与其他测试器官之间，在Ig-SC的总数、同种型分布以及个体发育过程中Ig-SC增加的动力学方面观察到了显著差异。针对SI中免疫反应的调节以及淋巴细胞在黏膜组织中的迁移模式，对这些差异进行了讨论。
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