Yoder M C, Lanker T A, Engle W A
Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46223.
Immunol Lett. 1988 Sep;19(1):1-6. doi: 10.1016/0165-2478(88)90111-3.
Varying culture medium oxygen tension from one-half to twice the normal concentration did not alter adult or cord blood monocyte-derived macrophage secretion of lysozyme or total protein. Lowering oxygen tension did result in significant increases in fibronectin concentration in both adult and cord blood macrophage culture supernatants. Dexamethasone (10(-7) M) completely blocked adult macrophage but had no effect on cord blood macrophage fibronectin release in response to lowering oxygen tension. These results indicate that human macrophages selectively regulate fibronectin production in response to changes in oxygen tension in vitro.
将培养基中的氧张力在正常浓度的一半至两倍之间变化，不会改变成人或脐血单核细胞衍生巨噬细胞溶菌酶或总蛋白的分泌。降低氧张力确实会导致成人和脐血巨噬细胞培养上清液中纤连蛋白浓度显著增加。地塞米松（10^(-7) M）完全阻断了成人巨噬细胞的反应，但对脐血巨噬细胞因氧张力降低而释放纤连蛋白没有影响。这些结果表明，人类巨噬细胞在体外会根据氧张力的变化选择性地调节纤连蛋白的产生。
