Gerdes J S, Douglas S D, Kolski G B, Yoder M C, Polin R A
J Leukoc Biol. 1984 Jan;35(1):91-9. doi: 10.1002/jlb.35.1.91.
Cultured cord blood monocytes synthesize significantly less fibronectin than cultured monocyte-macrophages from adult peripheral blood. Biosynthesis of the second component of complement in vitro is similar for both cell systems. The monocyte-macrophages from neonates and adults have similar functional and morphologic properties in long-term cultures. The decreased monocyte-macrophage biosynthesis of fibronectin observed in vitro may be in part related to the reduced plasma fibronectin concentrations and reticuloendothelial system hypofunction which occur in newborn infants.
培养的脐带血单核细胞合成的纤连蛋白明显少于培养的来自成人外周血的单核细胞-巨噬细胞。两种细胞系统在体外补体第二成分的生物合成相似。来自新生儿和成人的单核细胞-巨噬细胞在长期培养中具有相似的功能和形态学特性。体外观察到的单核细胞-巨噬细胞纤连蛋白生物合成减少可能部分与新生儿血浆纤连蛋白浓度降低和网状内皮系统功能减退有关。
