Zhang Yue, Qian Huizhu, Xu Jing, Gao Wen
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Ann Transl Med. 2019 Nov;7(22):686. doi: 10.21037/atm.2019.11.06.
Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep. Here, we review current important ADAR-mediated editing events, related carcinogenic mechanisms and applications in clinical medicine. Further exploration in ADARs can provide a new direction for cancer treatment.
作用于RNA的腺苷脱氨酶(ADARs)催化双链RNA中的腺苷(A)向肌苷(I)的转化,这可以在转录后改变密码子。异常的ADAR编辑存在于多种癌症中。然而,关于ADARs在癌症中的生物学效应的研究还不是很深入。在此,我们综述了当前重要的ADAR介导的编辑事件、相关致癌机制及其在临床医学中的应用。对ADARs的进一步探索可为癌症治疗提供新方向。