Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China.
Int J Mol Sci. 2023 Dec 26;25(1):351. doi: 10.3390/ijms25010351.
ADAR (Adenosine Deaminases Acting on RNA) proteins are a group of enzymes that play a vital role in RNA editing by converting adenosine to inosine in RNAs. This process is a frequent post-transcriptional event observed in metazoan transcripts. Recent studies indicate widespread dysregulation of ADAR-mediated RNA editing across many immune-related diseases, such as human cancer. We comprehensively review ADARs' function as pattern recognizers and their capability to contribute to mediating immune-related pathways. We also highlight the potential role of site-specific RNA editing in maintaining homeostasis and its relationship to various diseases, such as human cancers. More importantly, we summarize the latest cutting-edge computational approaches and data resources for predicting and analyzing RNA editing sites. Lastly, we cover the recent advancement in site-directed ADAR editing tool development. This review presents an up-to-date overview of ADAR-mediated RNA editing, how site-specific RNA editing could potentially impact disease pathology, and how they could be harnessed for therapeutic applications.
ADAR（Adenosine Deaminases Acting on RNA）蛋白是一组酶，通过将 RNA 中的腺苷转换为肌苷，在 RNA 编辑中发挥重要作用。这种过程是真核生物转录物中常见的转录后事件。最近的研究表明，ADAR 介导的 RNA 编辑在许多与免疫相关的疾病中广泛失调，如人类癌症。我们全面回顾了 ADAR 作为模式识别者的功能及其在介导免疫相关途径中的能力。我们还强调了特定于位点的 RNA 编辑在维持体内平衡中的潜在作用及其与各种疾病（如人类癌症）的关系。更重要的是，我们总结了用于预测和分析 RNA 编辑位点的最新计算方法和数据资源。最后，我们介绍了针对特定部位的 ADAR 编辑工具开发的最新进展。本综述介绍了 ADAR 介导的 RNA 编辑的最新概述，特定部位的 RNA 编辑如何可能影响疾病病理学，以及如何将其用于治疗应用。
Zotero 插件
