Aquatic Toxicology Research Laboratory, Department of Zoology, Aligarh Muslim University, Aligarh, U.P., India.
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P., India.
Mol Biol Rep. 2020 Mar;47(3):2289-2299. doi: 10.1007/s11033-020-05243-7. Epub 2020 Jan 13.
It is estimated that the global prevalence of dementia will rise as high as 24 million and predicted to be double in every 20 years which is attributed to the fact that the ageing population is increasing and so more individuals are at risk of developing neurodegenerative diseases like Alzheimer's. Many scientists favored glycation of proteins such as tau, amyloid beta (Aβ) etc. as one of the important risk factor in Alzheimer's disease (AD). Since, D-ribose shows highest glycation ability among other sugars hence, produces advanced glycation end products (AGEs) rapidly. However, there are several other mechanisms suggested by researchers through which D-ribose may cause cognitive impairments. There is a concern related to diabetic patients since they also suffer from D-ribose metabolism, may be more prone to AD risk. Thus, it is imperative that the pathogenesis and the pathways involved in AD progression are explored in the light of ribosylation and AGEs formation for identifying suitable diagnostics marker for early diagnosis or finding promising therapeutic outcomes.
据估计，全球痴呆症患病率将高达 2400 万，并预计每 20 年翻一番，这归因于人口老龄化的增加，因此更多的人面临着患神经退行性疾病（如阿尔茨海默病）的风险。许多科学家认为蛋白质的糖化，如 tau、淀粉样β（Aβ）等，是阿尔茨海默病（AD）的重要危险因素之一。由于 D-核糖在其他糖中显示出最高的糖化能力，因此能迅速产生晚期糖基化终末产物（AGEs）。然而，研究人员通过几种其他机制表明，D-核糖可能导致认知障碍。由于糖尿病患者也患有 D-核糖代谢，他们可能更容易患 AD 风险，因此人们关注这一点。因此，有必要根据核糖基化和 AGEs 的形成来探索 AD 进展中涉及的发病机制和途径，以确定用于早期诊断的合适诊断标志物或寻找有希望的治疗结果。
