Kanwugu Osman N, Helegbe Gideon K, Aryee Paul A, Abdul-Karim Abass, Anaba Frank, Ziblim Zulka, Amevi Evans D
Department of Biochemistry & Molecular Medicine, School of Medicine and Health Sciences, University for Development Studies, P. O. Box TL 1883, Tamale, Ghana.
Institute of Chemical Engineering, Ural Federal University, St. Mira 28, Yekaterinburg, Russia.
J Trop Med. 2019 Dec 21;2019:6457628. doi: 10.1155/2019/6457628. eCollection 2019.
Asymptomatic carriage of the malaria parasites, likewise its misdiagnosis, especially false negatives, due to the use of substandard rapid diagnosis tests (RDTs) has been shown to hinder the progress of the fight against malaria.
The study assessed the prevalence of asymptomatic malaria as well as the performance of -specific protein and histidine-rich protein 2 (HRP2) CareStart™ RDT against standard microscopy in the detection of malaria infection among 345 children (1-15 yrs) from two (2) basic schools in Tamale Metropolis.
From the microscopy (considered as gold standard), prevalence of malaria among the asymptomatic children was found to be 2.6%, with sensitivity and specificity of CareStart™ RDT in detecting infections found to be 55.6% and 93.8%, respectively. The positive predictive value (PPV) and negative predictive value (NPV) of CareStart™ RDT were found to be 19.23% and 98.45%, respectively. There was an evidence showing a significant relation between CareStart™ RDT and microscopy in determining malaria infection ( = 30.579, < 0.001).
Prevalence of asymptomatic malaria among children was found to be 2.6%. The study reported low sensitivity and PPV for HRP2 CareStart™ RDT in an asymptomatic population at instances of low parasitaemia.
疟原虫的无症状携带，同样还有其误诊情况，尤其是由于使用不合格的快速诊断检测（RDT）导致的假阴性，已被证明会阻碍疟疾防治工作的进展。
该研究评估了无症状疟疾的流行情况，以及在塔马利市两所基础学校的345名（1至15岁）儿童中，特异性蛋白和富含组氨酸蛋白2（HRP2）CareStart™ RDT在检测疟疾感染方面相对于标准显微镜检查的性能。
通过显微镜检查（被视为金标准），发现无症状儿童中的疟疾流行率为2.6%，CareStart™ RDT检测感染的敏感性和特异性分别为55.6%和93.8%。CareStart™ RDT的阳性预测值（PPV）和阴性预测值（NPV）分别为19.23%和98.45%。有证据表明，在确定疟疾感染方面，CareStart™ RDT与显微镜检查之间存在显著关联（χ² = 30.579，P < 0.001）。
发现儿童中无症状疟疾的流行率为2.6%。该研究报告称，在低疟原虫血症情况下，HRP2 CareStart™ RDT在无症状人群中的敏感性和PPV较低。
