McCallum R W, Ippoliti A F, Cooney C, Sturdevant R A
N Engl J Med. 1977 Feb 17;296(7):354-7. doi: 10.1056/NEJM197702172960702.
Since metoclopramide increases lower-esophageal-sphincter pressure in patients with gastroesophageal reflux, we compared the effects of metoclopramide, 10 mg four times daily, with those of placebo on symptoms in 31 patients with chronic heartburn. Eighteen patients completed a random-order, double-blind crossover study of two consecutive eight-week periods. The final 13 patients crossed over only if their symptoms were not substantially improved after the first eight weeks. Response of low-esophageal-sphincter pressure to metoclopramide did not correlate significantly with symptomatic improvement. After the metoclopramide treatment period, mean basal pressure was unchanged from values before study. In both treatment periods, metoclopramide-treated patients had significantly more symptomatic improvement than the control group (P less than 0.05).
由于甲氧氯普胺可增加胃食管反流患者的下食管括约肌压力，我们将每日4次、每次10毫克的甲氧氯普胺与安慰剂对31例慢性烧心患者症状的影响进行了比较。18例患者完成了一项连续两个八周周期的随机顺序、双盲交叉研究。最后的13例患者仅在最初八周后症状未显著改善时才进行交叉。下食管括约肌压力对甲氧氯普胺的反应与症状改善无显著相关性。在甲氧氯普胺治疗期后，平均基础压力与研究前的值无变化。在两个治疗期内，接受甲氧氯普胺治疗的患者症状改善明显多于对照组（P小于0.05）。
