Department of Neurology, New York University School of Medicine, New York, NY, USA; Department of Psychiatry, New York University School of Medicine, New York, NY, USA; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
Schizophr Res. 2020 May;219:13-18. doi: 10.1016/j.schres.2019.10.046. Epub 2020 Jan 11.
Optical coherence tomography (OCT) studies have demonstrated differences between people with schizophrenia and controls. Many questions remain including the agreement between scanners. The current study seeks to determine inter-device agreement of OCT data in schizophrenia compared to controls and to explore the relations between OCT and visual function measures.
Participants in this pilot study were 12 individuals with schizophrenia spectrum disorders and 12 age- and sex-matched controls. Spectralis and Cirrus OCT machines were used to obtain retinal nerve fiber layer (RNFL) thickness and macular volume. Cirrus was used to obtain ganglion cell layer + inner plexiform layer (GCL + IPL) thickness. Visual function was assessed with low-contrast visual acuity and the King-Devick test of rapid number naming.
There was excellent relative agreement in OCT measurements between the two machines, but poor absolute agreement, for both patients and controls. On both machines, people with schizophrenia showed decreased macular volume but no difference in RNFL thickness compared to controls. No between-group difference in GCL + IPL thickness was found on Cirrus. Controls showed significant associations between King-Devick performance and RNFL thickness and macular volume, and between low-contrast visual acuity and GCL + IPL thickness. Patients did not show significant associations between OCT measurements and visual function.
Good relative agreement suggests that the offset between machines remains constant and should not affect comparisons between groups. Decreased macular volume in individuals with schizophrenia on both machines supports findings of prior studies and provides further evidence that similar results may be found irrespective of OCT device.
光学相干断层扫描（OCT）研究表明精神分裂症患者与对照组之间存在差异。仍有许多问题悬而未决，包括扫描仪之间的一致性。本研究旨在确定与对照组相比，精神分裂症患者的 OCT 数据在不同设备之间的一致性，并探索 OCT 与视觉功能测量之间的关系。
本研究纳入了 12 名精神分裂症谱系障碍患者和 12 名年龄和性别匹配的对照组参与者。使用 Spectralis 和 Cirrus OCT 机器获得视网膜神经纤维层（RNFL）厚度和黄斑体积。使用 Cirrus 获得节细胞层+内丛状层（GCL+IPL）厚度。使用低对比度视力和 King-Devick 快速数字命名测试评估视觉功能。
对于患者和对照组，两种机器之间的 OCT 测量具有极好的相对一致性，但绝对一致性较差。与对照组相比，精神分裂症患者的黄斑体积减小，但 RNFL 厚度无差异。Cirrus 上未发现 GCL+IPL 厚度在两组之间存在差异。对照组的 King-Devick 表现与 RNFL 厚度和黄斑体积以及低对比度视力与 GCL+IPL 厚度之间存在显著相关性。患者的 OCT 测量与视觉功能之间未显示出显著相关性。
良好的相对一致性表明机器之间的偏移保持不变，不应影响组间比较。两种机器上精神分裂症患者的黄斑体积减小支持了先前研究的发现，并进一步证明无论 OCT 设备如何，都可能得出相似的结果。
