MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, Guangdong 510631, P. R. China.
Department of Physics and Optoelectronic Engineering, Foshan University, Guangdong, P. R. China.
J Mater Chem B. 2020 Feb 7;8(5):1040-1048. doi: 10.1039/c9tb02102g. Epub 2020 Jan 15.
By means of a simple and photo-induced method, four colors of molybdenum oxide quantum dots (MoO QDs) have been synthesized, using Mo(CO) as the structural guiding agent and molybdenum source. The as-prepared MoO QDs display diverse optical properties due to the different configurations of oxygen vacancies in various nanostructures. Among them, crystalline molybdenum dioxide (MoO) with a deep blue color shows the most intense localized surface plasmon resonance effect in the near-infrared (NIR) region. The strong NIR absorption endows MoO QDs with a high photothermal conversion efficiency of 66.3%, enabling broad prospects as a photo-responsive nanoagent for photothermal therapy of cancer. Moreover, MoO QDs can also serve as a novel semiconductor substrate for ultrasensitive surface-enhanced Raman scattering (SERS) analysis of aromatic molecules, amino acids and antibiotics, with SERS performance comparable to that of noble metal-based substrates. The therapeutic applications of MoO QDs open up a new avenue for tumor nanomedicine.
通过一种简单的光诱导方法，使用 Mo(CO) 作为结构导向剂和钼源，合成了四种颜色的氧化钼量子点 (MoO QDs)。所制备的 MoO QDs 由于不同纳米结构中氧空位的不同构型而表现出不同的光学性质。其中，具有深蓝色的结晶二氧化钼 (MoO) 在近红外 (NIR) 区域表现出最强的局域表面等离子体共振效应。强 NIR 吸收使 MoO QDs 具有 66.3%的高光热转换效率，有望成为癌症光热治疗的光响应纳米试剂。此外，MoO QDs 还可以作为一种新型半导体基底，用于芳香族分子、氨基酸和抗生素的超灵敏表面增强拉曼散射 (SERS) 分析，其 SERS 性能可与基于贵金属的基底相媲美。MoO QDs 的治疗应用为肿瘤纳米医学开辟了新途径。
