完美的时机：昼夜节律、睡眠和免疫——NIH 研讨会总结。
Perfect timing: circadian rhythms, sleep, and immunity - an NIH workshop summary.
机构信息
Division of Pulmonary, Critical Care and Sleep Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
JCI Insight. 2020 Jan 16;5(1):131487. doi: 10.1172/jci.insight.131487.
Abstract
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.
摘要
最近的发现表明，生物钟和睡眠对于免疫系统的稳态起着至关重要的作用。从白细胞的动员、迁移和趋化到细胞因子的释放和 T 细胞的分化，先天和适应性免疫反应都是按照时间依赖性的方式进行调节的。美国国立卫生研究院（NIH）最近主办了一个跨学科研讨会，题为“睡眠不足、昼夜节律失调与免疫反应”，旨在强调将睡眠和昼夜节律生物学与免疫功能联系起来的新研究，并确定具有高转化潜力的领域。这篇综述总结了讨论的主题，并强调了在生物节律、睡眠和免疫调节之间确定临床相关联系的即时机会。
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