Pawlotsky Y, Chales G, Coutard J, Meadeb J, Goasguen J, Lemaitre R, Ferrand P, Lejean F
Rev Rhum Mal Osteoartic. 1985 Jan;52(1):35-40.
A comparative study of the morning variation of the Sigma and Westergren sedimentation rates, and C-reactive protein was undertaken in 90 patients with osteoarticular disease (measurements at 07:00, 09:00, 10:00, and 12:00). The mean values of all three tests were elevated at 07:00 in patients with inflammatory disease, and no significant variation was observed in the Westergren sedimentation rate or C-reactive protein throughout the morning, irregardless of whether an anti-inflammatory agent was used. On the other hand, there was a very significant increase in the Sigma sedimentation rate at 09:00 in untreated patients (p less than 0.0001, n = 24). This morning increase of the Sigma sedimentation rate was not related to food intake, identical value being obtained in fasting or postprandial samples from the same patients. The Sigma sedimentation rate at 09:00 was significantly reduced however, in patients treated with an effective level of an anti-inflammatory agent (p less than 0.001, n = 32). This decrease varied in size and duration depending on the anti-inflammatory agent used. The existence of a circadian rhythm of the Sigma sedimentation rate which can be reversed with anti-inflammatory drug usage is helpful in understanding the chronobiologic aspects of the inflammatory process. Numerous therapeutic applications can be foreseen.
对90例骨关节炎患者的西格玛沉降率、魏氏沉降率和C反应蛋白的早晨变化进行了对比研究（于07:00、09:00、10:00和12:00进行测量）。炎症性疾病患者的这三项检测的平均值在07:00时均升高，且无论是否使用抗炎药，整个上午魏氏沉降率或C反应蛋白均未观察到显著变化。另一方面，未治疗患者的西格玛沉降率在09:00时显著升高（p<0.0001，n = 24）。西格玛沉降率的这种早晨升高与食物摄入无关，同一患者的空腹或餐后样本中得到相同的值。然而，在使用有效剂量抗炎药治疗的患者中，09:00时的西格玛沉降率显著降低（p<0.001，n = 32）。这种降低的幅度和持续时间因所使用的抗炎药而异。西格玛沉降率存在昼夜节律，且可被抗炎药使用逆转，这有助于理解炎症过程的时间生物学方面。可以预见许多治疗应用。
