Department of Chemistry, Oregon State University, Corvallis, Oregon, USA.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA.
Environ Toxicol Chem. 2021 Mar;40(3):677-688. doi: 10.1002/etc.4667. Epub 2020 Mar 22.
Toxicity reference values for per- and polyfluoroalkyl substances (PFAS) vary even when the same test organism is studied. Although the need to confirm dosing solution concentrations is widely accepted, there are no experimental data to inform best practices when PFAS solutions are prepared. Laboratory data indicate that dissolution time of PFAS solids causes statistically significant deviations between nominal and measured concentrations. Mixing times for select PFAS varied between 2 and 5 h, depending on carbon fluorine chain-length. Environ Toxicol Chem 2021;40:677-688. © 2020 SETAC.
毒性参考值对于全氟和多氟烷基物质（PFAS）即使在同一测试生物被研究时也有所不同。尽管人们普遍认为需要确认给药溶液浓度，但在制备 PFAS 溶液时，没有实验数据可以告知最佳实践。实验室数据表明，PFAS 固体的溶解时间会导致名义浓度和实测浓度之间存在统计学上的显著偏差。根据碳氟链长度的不同，某些 PFAS 的混合时间在 2 到 5 小时之间变化。环境毒理化学 2021；40:677-688。2020 年 SETAC 版权所有。
