尿三碘甲状腺原氨酸排泄量

Urinary triiodothyronine excretion.

作者信息

Orden I, Pié J, Juste M G, Giner A, Gómez M E, Escanero J F

机构信息

Departamento de Fisiología, Facultad de Medicina y Hospital Clínico Universitario, Zaragoza, Spain.

出版信息

Rev Esp Fisiol. 1988 Jun;44(2):179-84.

PMID:3194574

Abstract

The purpose of this work was to estimate the 24 h urinary excretion of free and conjugated triiodotironine (T3) using a direct radioimmunoassay and enzyme hydrolysis. Mean urinary values of free and total T3 (mean +/- 1 SD) in euthyroid controls were 2074 +/- 673 and 2819 +/- 809 pmol/24 h respectively. In patients with hyperthyroidism, values of free hormone were about 4.2 times higher than the mean value of the euthyroid controls, and about one-third in patients with hypothyroidism. These results show this measurement to be useful as an indicator of thyroid function. Mean renal clearance of free T3 was 211.6 +/- 62.8 ml/min (mean +/- 1 SD) in euthyroid controls, 260.8 +/- 87.5 ml/ml in hyperthyroid patients and 229 +/- 98.7 ml/min in hypothyroid patients. The data show that T3 renal clearance is, in all cases, greater than glomerular filtration rate, suggesting tubular secretion of T3.

摘要

本研究的目的是采用直接放射免疫分析法和酶水解法估算游离和结合型三碘甲状腺原氨酸（T3）的24小时尿排泄量。甲状腺功能正常的对照组中，游离T3和总T3的尿均值（均值±1标准差）分别为2074±673和2819±809 pmol/24小时。甲状腺功能亢进患者的游离激素值比甲状腺功能正常对照组的均值高约4.2倍，而甲状腺功能减退患者的该值约为对照组的三分之一。这些结果表明该测量可作为甲状腺功能的一项有用指标。甲状腺功能正常的对照组中，游离T3的平均肾清除率为211.6±62.8 ml/分钟（均值±1标准差），甲状腺功能亢进患者为260.8±87.5 ml/分钟，甲状腺功能减退患者为229±98.7 ml/分钟。数据显示，在所有情况下，T3的肾清除率均大于肾小球滤过率，提示T3存在肾小管分泌。