Aleksić S, Bockemühl J, Wuthe H H, Aleksić V
Medizinaluntersuchungsanstalt, Institute of Hygiene, Hamburg.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Aug;269(2):197-204. doi: 10.1016/s0176-6724(88)80096-8.
Despite its world-wide distribution, the pathogenic serogroup O: 5, 27 of Yersinia enterocolitica (Y. e.) has scarcely been considered in the Federal Republic of Germany. In the 1980 to 1986 period, a total of 74 strains from patients was identified at the National Reference Centre for Salmonella, Hamburg. The clinical manifestations of the cases was not different from those associated with Y. e. O: 3 and O: 9 infections. Six out of 8 patients from whom serum samples were available, developed moderate agglutination titres (1:80-1:1280). Only 8 of the 74 strains were negative in in vitro virulence tests. A list of biochemical tests is given which permit a differentiation of the pathogenic serogroup O: 5, 27 from the apathogenic Y. e. O: 5 which is widely distributed in the environment. Serological studies revealed different H antigens in both serogroups. The O antigen factor 27, and a subfactor O: 5(2) which is typical of Y. e. serogroup O: 5, are further differential markers; the production of both factor sera is described. Besides serogroups O: 3 and O: 9, Y. e. O: 5, 27 must be considered as an aetiological agent of human yersiniosis in the Federal Republic of Germany.
尽管小肠结肠炎耶尔森氏菌（Y. e.）的致病血清群O: 5, 27在全球范围内均有分布，但在德意志联邦共和国却几乎未被纳入考虑。在1980年至1986年期间，汉堡的国家沙门氏菌参考中心共鉴定出74株来自患者的菌株。这些病例的临床表现与O: 3和O: 9感染相关的临床表现并无差异。在可获取血清样本的8名患者中，有6人出现了中度凝集效价（1:80 - 1:1280）。74株菌株中只有8株在体外毒力试验中呈阴性。文中给出了一系列生化试验清单，可用于区分致病血清群O: 5, 27与环境中广泛分布的无致病性Y. e. O: 5。血清学研究揭示了这两个血清群中不同的H抗原。O抗原因子27以及典型的Y. e.血清群O: 5的一个亚因子O: 5(2)是进一步的鉴别标志物；文中描述了这两种因子血清的产生。除了O: 3和O: 9血清群外，Y. e. O: 5, 27也必须被视为德意志联邦共和国人类耶尔森氏菌病的病原体。
