MRI 评估骨质疏松症骨髓成分。
MRI Assessment of Bone Marrow Composition in Osteoporosis.
机构信息
Department of Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, 9500 Euclid Avenue, ND20, Cleveland, OH, 44195, USA.
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
出版信息
Curr Osteoporos Rep. 2020 Feb;18(1):57-66. doi: 10.1007/s11914-020-00562-x.
PURPOSE OF REVIEW
To provide an overview on recent technical development for quantifying marrow composition using magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques, as well as a summary on recent findings of interrelationship between marrow adipose tissue (MAT) and skeletal health in the context of osteoporosis.
RECENT FINDINGS
There have been significant technical advances in reliable quantification of marrow composition using MR techniques. Cross-sectional studies have demonstrated a negative correlation between MAT and bone, with trabecular bone associating more strongly with MAT than cortical bone. However, longitudinal studies of MAT and bone are limited. MAT contents and composition have been associated with prevalent vertebral fracture. The evidence between MAT and clinical fracture is more limited, and, to date, no studies have reported on the relationship between MAT and incident fracture. Increasing evidence suggests a dynamic role of marrow fat in skeletal health. Reliable non-invasive quantification of marrow composition will facilitate developing novel treatment strategies for osteoporosis.
目的综述
提供磁共振成像（MRI）和磁共振波谱（MRS）技术定量骨髓成分的最新技术发展概述，以及总结骨质疏松症背景下骨髓脂肪组织（MAT）与骨骼健康之间相互关系的最新发现。
最近的发现
使用磁共振技术可靠地定量骨髓成分方面取得了重大技术进展。横断面研究表明 MAT 与骨呈负相关，小梁骨与 MAT 的相关性强于皮质骨。然而，MAT 和骨的纵向研究有限。MAT 含量和组成与常见的椎体骨折有关。MAT 与临床骨折之间的证据更有限，迄今为止，尚无研究报告 MAT 与骨折事件之间的关系。越来越多的证据表明骨髓脂肪在骨骼健康中具有动态作用。可靠的非侵入性骨髓成分定量将有助于为骨质疏松症开发新的治疗策略。
Zotero 插件