Tan Y, Wang F, Fan G, Zheng Y, Li B, Li N, Liu Y, Wang X, Liu W, Krutmann J, Zou Y, Wang S
Department of Skin & Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, China.
Human Phenome Institute, Fudan University, Shanghai, China.
J Eur Acad Dermatol Venereol. 2020 Jul;34(7):1595-1600. doi: 10.1111/jdv.16206. Epub 2020 Feb 27.
Minimal erythema dose (MED) has substantial inter- and intraindividual variations, reflecting the influence of very diverse factors. However, related studies showed little consistency probably because of their limited sample size.
To identify the factors associated with MED variations in a large-scale population study.
The MED test was performed by following the international standard procedure on 22 146 subjects. The results were analysed in adjusted multivariable linear and logistic regression models.
This large-scale study revealed that lower MED was consistently associated with lighter skin [β-coefficient = -0.33, 95% confidence interval (CI) -0.36 to 0.30, P = 6.41 × 10 ]. Females had significantly higher MED than male (β = 0.91, 0.32-1.50, P = 2.93 × 10 ). Stratified analyses showed that MED was not associated with age [female: odds ratio (OR) = 0.99, 0.98-1.01; male: OR = 0.99, 0.97-1.00]. MED was lower in summer than in other seasons (spring: OR = 1.08, 1.06-1.11; autumn: OR = 1.11, 1.08-1.13; winter: OR = 1.20, 1.18-1.22). Furthermore, MED was associated with air temperature (β = -0.36, -0.49 to 0.23, P = 4.81 × 10 ) and air pressure (β = -0.64, -0.82 to 0.46, P = 8.01 × 10 ) in summer only while not in other seasons.
This study provides unprecedented evidence that MED is associated with skin colour, sex, season and meteorological factors, but not with age.
最小红斑量（MED）存在显著的个体间和个体内差异，反映了多种因素的影响。然而，相关研究的一致性较差，可能是因为样本量有限。
在大规模人群研究中确定与MED变化相关的因素。
按照国际标准程序对22146名受试者进行MED测试。在调整后的多变量线性和逻辑回归模型中分析结果。
这项大规模研究表明，较低的MED始终与较浅的肤色相关[β系数=-0.33，95%置信区间（CI）-0.36至-0.30，P=6.41×10]。女性的MED显著高于男性（β=0.91，0.32-1.50，P=2.93×10）。分层分析表明，MED与年龄无关[女性：比值比（OR）=0.99，0.98-1.01；男性：OR=0.99，0.97-1.00]。夏季的MED低于其他季节（春季：OR=1.08，1.06-1.11；秋季：OR=1.11，1.08-1.13；冬季：OR=1.20，1.18-1.22）。此外，仅在夏季MED与气温（β=-0.36，-0.49至-0.23，P=4.81×10）和气压（β=-0.64，-0.82至-0.46，P=8.01×10）相关，而在其他季节则不相关。
本研究提供了前所未有的证据，表明MED与肤色、性别、季节和气象因素有关，但与年龄无关。
