Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Pointe-à-Pitre, France.
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM U1018, Cancer and Environment team, Villejuif, France.
Occup Environ Med. 2020 May;77(5):293-300. doi: 10.1136/oemed-2019-106080. Epub 2020 Jan 20.
To investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the nvestigation of occupational and environmental uses of spiratory cancers study.
Analyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.
Welding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer.
Our findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.
在一项大型法国基于人群的病例对照研究——职业和环境因素与呼吸癌症的关系研究中，调查职业接触焊接与头颈部癌症风险的相关性。
分析仅限于男性（2703 名对照者和 1588 名口腔、口咽、下咽和喉鳞状细胞癌病例）。通过详细的问卷评估焊接活动和潜在的混杂因素。使用非条件逻辑回归估计比值比（OR）和 95%置信区间（95%CI），调整年龄、居住地区、吸烟、饮酒和接触石棉的职业暴露等因素。
焊接与头颈部癌症的总体风险增加相关（OR=1.31，95%CI 1.03 至 1.67）。喉癌的相关性最强（OR=1.66，95%CI 1.15 至 2.38），且风险随累积时间（趋势检验<0.01）和加权时间（趋势检验<0.01）的增加而增加。累积时间和焊接加权时间超过 10 年也与口腔癌的显著增加风险相关（OR=1.82，95%CI 1.09 至 3.04；OR=2.10，95%CI 0.99 至 4.45）。电弧焊接的长时间与喉癌相关，而点焊的长时间与口腔癌相关。焊接与口咽和下咽癌的风险无关。
我们的研究结果表明，焊接和几种与焊接相关的工作增加了患喉癌的风险，且在一定程度上增加了患口腔癌的风险。
