Department of Otorhinolaryngology-Head and Neck Surgery, HUS Helsinki University Hospital, University of Helsinki, FI-00029 Helsinki, Finland.
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, FI-00139 Helsinki, Finland.
Int J Environ Res Public Health. 2023 Nov 3;20(21):7020. doi: 10.3390/ijerph20217020.
While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose-response analyses adequately adjusted for confounders.
虽然有大量证据表明酒精、烟草和 HPV 感染会对口咽产生致癌影响，但吸入性工作场所危害的作用仍未明确界定。我们旨在确定文献中是否揭示了职业环境患口咽癌 (OPC) 的风险高于平均水平，并总结现有数据。为了确定评估职业暴露与 OPC 风险之间关系的研究，通过 PubMed-NCBI 数据库进行了文献检索，最终选择了 15 篇符合入选标准的原始文章。仅纳入了专注于职业暴露与 OPC 风险或死亡之间关联的英文原始文章。现有数据支持在服务员、厨师和服务员、艺术工作者、家禽和肉类工作者、机械师以及暴露于灰尘的世界贸易中心救援人员中，OPC 的风险可能会增加。然而，关于与职业相关的 OPC 的现有文献有限。为了确定有风险的职业类别，需要有长期随访的大型队列。要确定与职业相关因素的因果关联，需要进行适当调整混杂因素的剂量-反应分析。
