快速纳米孔全基因组测序在炭疽应急准备中的应用。
Rapid Nanopore Whole-Genome Sequencing for Anthrax Emergency Preparedness.
出版信息
Emerg Infect Dis. 2020 Feb;26(2):358-361. doi: 10.3201/eid2602.191351.
Abstract
Human anthrax cases necessitate rapid response. We completed Bacillus anthracis nanopore whole-genome sequencing in our high-containment laboratory from a human anthrax isolate hours after receipt. The de novo assembled genome showed no evidence of known antimicrobial resistance genes or introduced plasmid(s). Same-day genomic characterization enhances public health emergency response.
摘要
人感染炭疽病例需要快速应对。我们在高防护实验室中，在收到人感染炭疽分离株后的数小时内，完成了对其进行的 Bacillus anthracis nanopore 全基因组测序。从头组装的基因组未显示出已知抗微生物药物耐药基因或引入质粒的证据。当天进行基因组特征分析可增强公共卫生应急响应。
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