Mohler F S, Gordon C J
United States Environmental Protection Agency, Health Effects Research Laboratory, Research Triangle Park, North Carolina 27711.
Arch Toxicol. 1988;62(2-3):216-9. doi: 10.1007/BF00570143.
Earlier studies have shown that intraperitoneal injection of the industrial solvent sulfolane (tetrahydrothiophene-1,1-dioxide) caused a decrease in metabolic rate and a rapid, regulated hypothermia in mice and rats. In the present study, subcutaneous injections of 0, 100, 200, 400, 600, and 750 mg/kg sulfolane at an ambient temperature (Ta) of 10 degrees C caused a dose-dependent decrease in colonic temperature (Tc) of rabbits. Metabolic rate (MR) remained unchanged during the initial phase of the hypothermia for all dose groups; but peripheral vasodilation, as indicated by an increase in ear skin temperature, was seen at the higher dose levels. The observed thermoregulatory response to sulfolane was a function of Ta. Thus, at Tas of 10 and 20 degrees C, injection of 600 mg/kg sulfolane had no effect on MR but caused an increase in ear skin temperature. The magnitude of the hypothermia was similar at these two Tas, indicating the sulfolane-treated rabbits had some control over Tc. At a Ta of 28 degrees C, however, the animals became hyperthermic upon injection of 600 mg/kg sulfolane.
早期研究表明，给小鼠和大鼠腹腔注射工业溶剂环丁砜（四氢噻吩 - 1,1 - 二氧化物）会导致代谢率下降以及快速、有调节的体温过低。在本研究中，在环境温度（Ta）为10摄氏度时，给家兔皮下注射0、100、200、400、600和750毫克/千克的环丁砜，会导致家兔结肠温度（Tc）呈剂量依赖性下降。在体温过低的初始阶段，所有剂量组的代谢率（MR）均保持不变；但在较高剂量水平时，出现了耳皮肤温度升高所表明的外周血管舒张。观察到的对环丁砜的体温调节反应是Ta的函数。因此，在Ta为10和20摄氏度时，注射600毫克/千克的环丁砜对MR没有影响，但会导致耳皮肤温度升高。在这两个Ta下，体温过低的程度相似，表明经环丁砜处理的家兔对Tc有一定的控制能力。然而，在Ta为28摄氏度时，注射600毫克/千克的环丁砜后动物会出现体温过高。
