Gordon C J, Long M D, Fehlner K S, Dyer R S
Environ Res. 1986 Jun;40(1):92-7. doi: 10.1016/s0013-9351(86)80084-6.
Mice injected intraperitoneally with sulfolane (tetrahydrothiophene-1,1-dioxide) underwent a significant decrease in metabolic rate and body temperature at ambient temperatures of 20 and 30 degrees C but not 35 degrees C. If given the opportunity, mice treated with sulfolane preferentially sought a cool ambient temperature. When given an LD50 dose of sulfolane (1270 mg/kg), the percentage mortality varied directly with ambient temperature. For example, at 35 degrees C mortality was 75% whereas at 25 degrees C mortality was only 8%. By undergoing an autonomically and behaviorally mediated decrease in body temperature (i.e., regulated hypothermia), sulfolane-treated mice appear to enhance their chance of survival.
腹腔注射环丁砜（四氢噻吩 -1,1-二氧化物）的小鼠，在20摄氏度和30摄氏度的环境温度下代谢率和体温显著下降，但在35摄氏度时则不然。如果有机会，用环丁砜处理过的小鼠会优先寻找凉爽的环境温度。当给予环丁砜半数致死剂量（1270毫克/千克）时，死亡率与环境温度直接相关。例如，在35摄氏度时死亡率为75%，而在25摄氏度时死亡率仅为8%。通过自主和行为介导的体温下降（即调节性体温过低），用环丁砜处理过的小鼠似乎提高了它们的生存几率。
