Ruppert P H, Dyer R S
Toxicol Lett. 1985 Nov;28(2-3):111-6. doi: 10.1016/0378-4274(85)90018-9.
Sulfolane is a solvent which produces hypothermia and decreased oxygen consumption following acute exposure. In the present experiment, we investigated effects of sulfolane on a behavioral measure of toxicity at ambient temperatures which would either prevent or facilitate the development of hypothermia. Adult male Long-Evans rats (N = 10/dose) received a single i.p. injection of saline, 200, 400 or 800 mg/kg sulfolane. Motor activity in figure-of-eight mazes was assessed 1 h after dosing in testing rooms maintained at either 20.8 degrees C or at 32.3 degrees C. At the warm ambient temperature, sulfolane produced hypoactivity but not hypothermia. At the cooler temperature, sulfolane-induced hypoactivity was more pronounced, and rats were hypothermic. Therefore, a behavioral change could be detected at sublethal dosages of sulfolane in the absence of hypothermia.
环丁砜是一种在急性接触后会导致体温过低和耗氧量降低的溶剂。在本实验中，我们研究了环丁砜在环境温度下对毒性行为指标的影响，这种环境温度要么会阻止要么会促进体温过低的发展。成年雄性长爪沙鼠（每组10只）腹腔注射生理盐水、200、400或800毫克/千克环丁砜。给药1小时后，在保持在20.8摄氏度或32.3摄氏度的测试室中评估其在八字形迷宫中的运动活动。在温暖的环境温度下，环丁砜会导致活动减少但不会导致体温过低。在较冷的温度下，环丁砜引起的活动减少更为明显，并且大鼠体温过低。因此，在环丁砜的亚致死剂量下，在没有体温过低的情况下也能检测到行为变化。
