猪流行性腹泻病毒（CV 777）与猫传染性腹膜炎病毒（FIPV）在抗原性上相关。
Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related.
作者信息
Zhou Y L, Ederveen J, Egberink H, Pensaert M, Horzinek M C
机构信息
Institute of Virology, Veterinary Faculty, State University, Utrecht, The Netherlands.
出版信息
Arch Virol. 1988;102(1-2):63-71. doi: 10.1007/BF01315563.
Abstract
Using gut sections from pigs infected with porcine epidemic diarrhea virus (strain CV 777) and ascitic fluid from cats which had succumbed to feline infectious peritonitis (FIP), a weak cross reaction was found by immunofluorescence. Its specificity was confirmed when detergent-treated purified CV 777 showed a prominent reaction with FIPV antibodies in ELISA; no reaction was obtained with intact virions, which indicated common determinants on an internal component of the particle. Antigenic cross-reactions at the nucleocapsid level were found in Western blot ELISA performed both ways (CV 777/FIPV antibodies; FIPV/CV 777 antibodies). In immunoprecipitation using [35S]methionine labelled FIPV, anti-CV 777 sera recognized exclusively the nucleocapsid protein. The significance of these findings for the classification of coronaviruses is discussed.
摘要
利用感染猪流行性腹泻病毒（CV 777株）的猪的肠道组织切片以及死于猫传染性腹膜炎（FIP）的猫的腹水，通过免疫荧光发现了微弱的交叉反应。当用去污剂处理的纯化CV 777在酶联免疫吸附测定（ELISA）中与猫传染性腹膜炎病毒（FIPV）抗体呈现显著反应时，其特异性得到了证实；完整病毒粒子未出现反应，这表明在病毒粒子内部成分上存在共同的决定簇。在双向进行的蛋白质印迹ELISA（CV 777/FIPV抗体；FIPV/CV 777抗体）中发现了核衣壳水平的抗原交叉反应。在使用[35S]甲硫氨酸标记的FIPV进行的免疫沉淀中，抗CV 777血清仅识别核衣壳蛋白。本文讨论了这些发现对冠状病毒分类的意义。
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Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related.猪流行性腹泻病毒（CV 777）与猫传染性腹膜炎病毒（FIPV）在抗原性上相关。
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