Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", Via Tronto 10/A, 60126, Ancona, Italy.
Department of Biomedical Sciences and Public Health, School of Medicine, University "Politecnica delle Marche", Via Tronto 10/A, 60126, Ancona, Italy.
Cell Calcium. 2020 Mar;86:102160. doi: 10.1016/j.ceca.2020.102160. Epub 2020 Jan 13.
Energy metabolism impairment is a central event in the pathophysiology of ischemia. The limited availability of glucose and oxygen strongly affects mitochondrial activity, thus leading to ATP depletion. In this setting, the switch to alternative energy sources could ameliorate cells survival by enhancing ATP production, thus representing an attractive strategy for ischemic treatment. In this regard, some studies have recently re-evaluated the metabolic role of glutamate and its potential to promote cell survival under pathological conditions. In the present review, we discuss the ability of glutamate to exert an "energizing role" in cardiac and neuronal models of hypoxia/reoxygenation (H/R) injury, focusing on the Na/Ca exchanger (NCX) and the Na-dependent excitatory amino acid transporters (EAATs) as key players in this metabolic pathway.
能量代谢障碍是缺血病理生理学的中心事件。葡萄糖和氧气的有限供应强烈影响线粒体活性，从而导致 ATP 耗竭。在这种情况下，切换到替代能源可以通过增强 ATP 产生来改善细胞存活，因此代表了一种有吸引力的缺血治疗策略。在这方面，一些研究最近重新评估了谷氨酸的代谢作用及其在病理条件下促进细胞存活的潜力。在本综述中，我们讨论了谷氨酸在缺氧/复氧（H/R）损伤的心脏和神经元模型中发挥“能量作用”的能力，重点关注 Na/Ca 交换器（NCX）和 Na 依赖性兴奋性氨基酸转运体（EAATs）作为该代谢途径中的关键参与者。
