Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, 524023, China; The Marine Biomedical Research Institute, Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China; Cancer Center, The Affiliated Hospital, Guangdong Medical University, Zhanjiang 524023, China.
The Marine Biomedical Research Institute, Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China.
Biomed Pharmacother. 2020 Apr;124:109821. doi: 10.1016/j.biopha.2020.109821. Epub 2020 Jan 18.
Cancer immunotherapy is an innovative treatment for tumors today. In various experiments and clinical studies, it has been found that immunotherapy does have incomparable advantages over traditional anti-tumor therapy, which can prolong progression-free survival (PFS) and overall survival (OS). However, immunotherapy has obvious complexity and uncertainty. Immunotherapy may also cause severe adverse reactions due to an overactive immune system. More effective and fewer adverse reactions immunological checkpoints are still under further exploration. This review gives an overview of recent developments in immunotherapy and indicates a new direction of tumor treatment through analyzing the pros and cons of immunotherapy coupled with keeping a close watch on the development trend of the immunotherapy future.
癌症免疫疗法是当今肿瘤治疗的一种创新手段。在各种实验和临床研究中,已经发现免疫疗法确实比传统的抗肿瘤疗法具有无可比拟的优势,可以延长无进展生存期(PFS)和总生存期(OS)。但是,免疫疗法具有明显的复杂性和不确定性。由于免疫系统过度活跃,免疫疗法也可能引起严重的不良反应。更有效和更少不良反应的免疫检查点仍在进一步探索中。通过分析免疫疗法的优缺点,并密切关注免疫疗法未来的发展趋势,本文综述了免疫疗法的最新进展,为肿瘤治疗指明了一个新的方向。