Ideue Takashi, Tani Tokio
Department of Biological Sciences, Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Noncoding RNA. 2020 Jan 17;6(1):4. doi: 10.3390/ncrna6010004.
Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on the chromosomes. Centromeres are specific regions where kinetochores assemble. Although these regions were previously considered to be silent, some experimental studies have demonstrated that transcription occurs in these regions to generate non-coding RNAs (ncRNAs). These centromeric ncRNAs (cenRNAs) are involved in centromere functions. Here, we describe the currently available information on the functions of cenRNAs in several species.
染色体分离受到严格调控，以确保遗传物质正确分配到子细胞中。在此过程中，有丝分裂染色体被附着在染色体上组装的动粒的微管束拉向两极。着丝粒是动粒组装的特定区域。尽管这些区域以前被认为是沉默的，但一些实验研究表明，这些区域会发生转录以产生非编码RNA（ncRNA）。这些着丝粒ncRNA（cenRNA）参与着丝粒功能。在这里，我们描述了目前关于几种物种中cenRNA功能的可用信息。
