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暴露于环境放射性核素的小林姬鼠基因组中核糖体DNA和着丝粒周围卫星重复序列的扩增。

Expansion of rDNA and pericentromere satellite repeats in the genomes of bank voles exposed to environmental radionuclides.

作者信息

Jernfors Toni, Danforth John, Kesäniemi Jenni, Lavrinienko Anton, Tukalenko Eugene, Fajkus Jiří, Dvořáčková Martina, Mappes Tapio, Watts Phillip C

机构信息

Department of Biological and Environmental Science University of Jyväskylä Jyväskylä Finland.

Department of Biochemistry & Molecular Biology Robson DNA Science Centre Arnie Charbonneau Cancer Institute Cumming School of Medicine University of Calgary Calgary Canada.

出版信息

Ecol Evol. 2021 May 25;11(13):8754-8767. doi: 10.1002/ece3.7684. eCollection 2021 Jul.

DOI:10.1002/ece3.7684
PMID:34257925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8258220/
Abstract

Altered copy number of certain highly repetitive regions of the genome, such as satellite DNA within heterochromatin and ribosomal RNA loci (rDNA), is hypothesized to help safeguard the genome against damage derived from external stressors. We quantified copy number of the 18S rDNA and a pericentromeric satellite DNA (Msat-160) in bank voles () inhabiting the Chernobyl Exclusion Zone (CEZ), an area that is contaminated by radionuclides and where organisms are exposed to elevated levels of ionizing radiation. We found a significant increase in 18S rDNA and Msat-160 content in the genomes of bank voles from contaminated locations within the CEZ compared with animals from uncontaminated locations. Moreover, 18S rDNA and Msat-160 copy number were positively correlated in the genomes of bank voles from uncontaminated, but not in the genomes of animals inhabiting contaminated, areas. These results show the capacity for local-scale geographic variation in genome architecture and are consistent with the genomic safeguard hypothesis. Disruption of cellular processes related to genomic stability appears to be a hallmark effect in bank voles inhabiting areas contaminated by radionuclides.

摘要

基因组某些高度重复区域的拷贝数改变，如异染色质内的卫星DNA和核糖体RNA基因座（rDNA），被认为有助于保护基因组免受外部应激源造成的损伤。我们对生活在切尔诺贝利禁区（CEZ）的林姬鼠（）中的18S rDNA和着丝粒周围卫星DNA（Msat-160）的拷贝数进行了量化，该区域受到放射性核素污染，生物暴露于高水平的电离辐射中。我们发现，与未受污染地区的动物相比，CEZ内受污染地区的林姬鼠基因组中18S rDNA和Msat-160的含量显著增加。此外，未受污染地区的林姬鼠基因组中18S rDNA和Msat-160的拷贝数呈正相关，但在受污染地区的动物基因组中则不然。这些结果显示了基因组结构在局部尺度上的地理变异能力，并且与基因组保护假说一致。与基因组稳定性相关的细胞过程的破坏似乎是生活在受放射性核素污染地区的林姬鼠的一个标志性效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/d29d12b764bc/ECE3-11-8754-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/e12778c513bb/ECE3-11-8754-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/1ae81c7dac76/ECE3-11-8754-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/1b69d7cae7f7/ECE3-11-8754-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/0f6dfd98e1f2/ECE3-11-8754-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/d29d12b764bc/ECE3-11-8754-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/e12778c513bb/ECE3-11-8754-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/1ae81c7dac76/ECE3-11-8754-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/1b69d7cae7f7/ECE3-11-8754-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/0f6dfd98e1f2/ECE3-11-8754-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6381/8258220/d29d12b764bc/ECE3-11-8754-g005.jpg

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