预防复发性酵母菌和细菌性阴道感染：乳铁蛋白和乳酸菌
Warding Off Recurrent Yeast and Bacterial Vaginal Infections: Lactoferrin and Lactobacilli.
作者信息
Superti Fabiana, De Seta Francesco
机构信息
National Centre for Innovative Technologies in Public Health, National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", University of Trieste, via dell'Istria 65/1, 34137 Trieste, Italy.
出版信息
Microorganisms. 2020 Jan 17;8(1):130. doi: 10.3390/microorganisms8010130.
Abstract
Vaginal infections are the most prevalent women's health problem. Incompetent diagnosis, inappropriate treatments, and antibiotic resistance are the main causes of the unsatisfactory results of conventional, antimicrobic treatment for these infections. Research has thus been conducted to identify new treatments for these genital diseases. The significant enhancement in our knowledge of vaginal microbiota has permitted the development of new, nonpharmacological strategies for the treatment of vaginal infections that seek to restore the balance of vaginal microflora, as opposed to modifying its components. Among these approaches, bioactive compounds, such as probiotics and nutraceutical proteins (such as lactoferrin), deserve particular attention. The aim of this review is to examine the role of probiotics (mainly spp.) and lactoferrin as new strategies for counteracting bacterial and fungal vaginal infections.
摘要
阴道感染是最普遍的女性健康问题。诊断不当、治疗不合适以及抗生素耐药性是这些感染的传统抗菌治疗效果不尽人意的主要原因。因此，人们开展了研究以确定这些生殖器疾病的新治疗方法。我们对阴道微生物群的了解有了显著提高，这使得开发新的非药物治疗策略成为可能，这些策略旨在恢复阴道微生物群的平衡，而不是改变其组成部分。在这些方法中，生物活性化合物，如益生菌和营养蛋白（如乳铁蛋白），值得特别关注。本综述的目的是研究益生菌（主要是 属）和乳铁蛋白作为对抗细菌性和真菌性阴道感染的新策略的作用。
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