Wu Yu-Ru, Chen Jung-Sheng, Chen Lei-Chin, Chen Laura, Huang Yu-Fen, Liao Chien-Sen
Department of Medical Science and Biotechnology, I-Shou University, Kaohsiung 824005, Taiwan.
Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung 824005, Taiwan.
Pathogens. 2025 Mar 24;14(4):308. doi: 10.3390/pathogens14040308.
Vulvovaginal candidiasis (VVC) is a common gynecological condition primarily caused by . The excessive use of antifungal drugs has led to increased drug resistance, necessitating the search for alternative therapies. This study investigates the synergistic antifungal effects of cranberry proanthocyanidins (PACs) and probiotics against . PACs were prepared at different concentrations (low, medium, high) and tested alone and in combination with multi-strain probiotics, including and . The antifungal activity of their cell-free supernatants (CFS) was also assessed. The results demonstrated that the combination of and medium-concentration PACs (L.p. + PACs M) significantly enhathe inhibitionition of compared to individual treatments. In the Vaginal Microbiota Communities Analysis, this condition reduced relative abundance to below 0.01%. This study highlights the potential of natural compounds and probiotics as alternative therapeutic strategies for VVC.
外阴阴道念珠菌病（VVC）是一种常见的妇科疾病，主要由……引起。抗真菌药物的过度使用导致耐药性增加，因此需要寻找替代疗法。本研究调查了蔓越莓原花青素（PACs）和益生菌对……的协同抗真菌作用。制备了不同浓度（低、中、高）的PACs，并单独以及与多种益生菌（包括……和……）联合进行测试。还评估了它们的无细胞上清液（CFS）的抗真菌活性。结果表明，与单独处理相比，……和中浓度PACs（L.p. + PACs M）的组合显著增强了对……的抑制作用。在阴道微生物群落分析中，这种情况将……的相对丰度降低到0.01%以下。本研究强调了天然化合物和益生菌作为VVC替代治疗策略的潜力。
