用于胶质母细胞瘤治疗的纳米疗法
Nano-Therapies for Glioblastoma Treatment.
作者信息
Alphandéry Edouard
机构信息
Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie, IMPMC, Sorbonne Université, Muséum National d'Histoire Naturelle, UMR CNRS 7590, IRD Place Jussieu, 75005 Paris, France.
Nanobacterie SARL, 36 boulevard Flandrin, 75116 Paris, France.
出版信息
Cancers (Basel). 2020 Jan 19;12(1):242. doi: 10.3390/cancers12010242.
Traditional anti-cancer treatments are inefficient against glioblastoma, which remains one of the deadliest and most aggressive cancers. Nano-drugs could help to improve this situation by enabling: (i) an increase of anti-glioblastoma multiforme (GBM) activity of chemo/gene therapeutic drugs, notably by an improved diffusion of these drugs through the blood brain barrier (BBB), (ii) the sensibilization of radio-resistant GBM tumor cells to radiotherapy, (iii) the removal by surgery of infiltrating GBM tumor cells, (iv) the restoration of an apoptotic mechanism of GBM cellular death, (v) the destruction of angiogenic blood vessels, (vi) the stimulation of anti-tumor immune cells, e.g., T cells, NK cells, and the neutralization of pro-tumoral immune cells, e.g., T cells, (vii) the local production of heat or radical oxygen species (ROS), and (viii) the controlled release/activation of anti-GBM drugs following the application of a stimulus. This review covers these different aspects.
传统的抗癌治疗方法对胶质母细胞瘤无效，而胶质母细胞瘤仍然是最致命、最具侵袭性的癌症之一。纳米药物有助于改善这种情况，具体方式包括：（i）提高化学/基因治疗药物对多形性胶质母细胞瘤（GBM）的活性，特别是通过改善这些药物通过血脑屏障（BBB）的扩散；（ii）使耐辐射的GBM肿瘤细胞对放疗敏感；（iii）通过手术清除浸润性GBM肿瘤细胞；（iv）恢复GBM细胞死亡的凋亡机制；（v）破坏血管生成血管；（vi）刺激抗肿瘤免疫细胞，如T细胞、NK细胞，并中和促肿瘤免疫细胞，如T细胞；（vii）局部产生热量或活性氧（ROS）；（viii）在施加刺激后控制抗GBM药物的释放/激活。本综述涵盖了这些不同方面。
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