Kiskova Terezia, Kubatka Peter, Büsselberg Dietrich, Kassayova Monika
Department of Animal Physiology, Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University, 04154 Kosice, Slovakia.
Department of Medical Biology and Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
Biomolecules. 2020 Jan 19;10(1):161. doi: 10.3390/biom10010161.
Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood‒brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clinical research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.
尽管进行了深入研究，但恶性脑肿瘤由于对传统治疗方法具有高度抗性，仍是最难治疗的疾病之一。高级别恶性胶质瘤，包括胶质母细胞瘤和间变性星形细胞瘤，是最具毁灭性且生长迅速的癌症类型。尽管标准治疗药物能够在脑内达到治疗浓度，但恶性胶质瘤通常对烷化剂具有抗性。白藜芦醇是一种存在于坚果、浆果、葡萄和红酒中的植物多酚。白藜芦醇能够穿过血脑屏障，并可能影响中枢神经系统。此外，它会影响异柠檬酸脱氢酶，更重要的是，它通过多种机制影响对标准治疗的抗性，如O6-甲基鸟嘌呤甲基转移酶。本综述总结了白藜芦醇在各类脑癌中的抗癌作用。多项体外和体内研究已呈现出有前景的结果；然而，需要进一步的临床研究来证明白藜芦醇在脑癌治疗中的疗效。
