低危前列腺癌患者的种族、肿瘤位置和疾病进展。
Race, tumor location, and disease progression among low-risk prostate cancer patients.
机构信息
Urology Service, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
出版信息
Cancer Med. 2020 Mar;9(6):2235-2242. doi: 10.1002/cam4.2864. Epub 2020 Jan 21.
BACKGROUND
The relationship between race, prostate tumor location, and BCR-free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence-free (BCR) survival.
METHODS
A retrospective cohort study was conducted among men with newly diagnosed, biopsy-confirmed, NCCN-defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008. BCR-free survival was modeled using Kaplan-Meier estimation curves and multivariable Cox proportional hazards (PH) analyses.
RESULTS
There were 539 eligible patients with low-risk CaP (25% African American, AA; 75% Caucasian American, CA). Median age at CaP diagnosis and post-RP follow-up time was 59.2 and 8.1 years, respectively. Kaplan-Meier analyses showed no significant association between race (P = .52) or predominant tumor location (P = .98) on BCR-free survival. In Cox PH multivariable analysis, neither race (HR = 1.18; 95% CI = 0.68-2.02; P = .56) nor predominant tumor location (HR = 1.13; 95% CI = 0.59-2.15; P = .71) was an independent predictor of BCR-free survival.
CONCLUSIONS
Neither race nor predominant tumor location was associated with adverse oncologic outcome.
背景
种族、前列腺肿瘤位置与 BCR 无复发生存之间的关系尚无定论。本研究探讨了患者种族和肿瘤位置对生化无复发生存（BCR）的独立和共同作用。
方法
对 1996 年至 2008 年期间在 Walter Reed 国家军事医学中心接受根治性前列腺切除术（RP）的新诊断、经活检证实、NCCN 定义的低危 CaP 男性进行了回顾性队列研究。使用 Kaplan-Meier 估计曲线和多变量 Cox 比例风险（PH）分析来建模 BCR 无复发生存。
结果
共有 539 名符合条件的低危 CaP 患者（25%为非裔美国人，AA；75%为白种人，CA）。CaP 诊断和 RP 后随访时间的中位数分别为 59.2 岁和 8.1 年。Kaplan-Meier 分析显示种族（P=.52）或主要肿瘤位置（P=.98）与 BCR 无复发生存之间无显著相关性。在 Cox PH 多变量分析中，种族（HR=1.18；95%CI=0.68-2.02；P=.56）和主要肿瘤位置（HR=1.13；95%CI=0.59-2.15；P=.71）均不是 BCR 无复发生存的独立预测因素。
结论
种族和主要肿瘤位置均与不良肿瘤学结果无关。
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