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回肠系膜原发性低分化单相滑膜肉瘤伴肺转移:一例报告

Primary poorly differentiated monophasic synovial sarcoma of ileum mesenteries with pulmonary metastasis: a case report.

作者信息

Ding Li, Han Anjia

机构信息

Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou, China.

出版信息

Int J Clin Exp Pathol. 2017 Nov 1;10(11):11143-11146. eCollection 2017.

Abstract

Primary intra-abdominal synovial sarcomas are rare soft tissue malignancies. Herein, we present a case of poorly differentiated monophasic synovial sarcomain ileum mesenterieswith pulmonary metastasis. The patient was a 47-year-old female with a history of cough with variable expectoration and paroxysmal abdominal pain for two months. The tumor was located in ileum mesenteries and composed of monophasic spindle tumor cells with active mitosis and massive necrosis. Tumor cells were positive for vimentin and BCL-2 by immunohistochemistry staining and positive for SYT gene break apart by dual color break apart fluorescence in situ hybridization assay. The differential diagnosis includes gastrointestinal stromal tumour and other mesenchymal tumour.

摘要

原发性腹腔滑膜肉瘤是罕见的软组织恶性肿瘤。在此,我们报告一例发生于回肠系膜的低分化单相滑膜肉瘤伴肺转移的病例。患者为47岁女性,有两个月咳嗽伴咳痰及阵发性腹痛病史。肿瘤位于回肠系膜,由单相梭形肿瘤细胞组成,有活跃的有丝分裂和大片坏死。免疫组化染色显示肿瘤细胞波形蛋白和BCL-2阳性,双色分离荧光原位杂交检测SYT基因分离阳性。鉴别诊断包括胃肠道间质瘤和其他间叶性肿瘤。

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